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Listar Artículos (Química Orgánica y Farmacéutica) por autor "Recio Jiménez, Rocío"
Mostrando ítems 1-18 de 18
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Artículo
An Efficient and Practical Method for the Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols
Borrego Sánchez de la Cuesta, Lorenzo Gabriel; Recio Jiménez, Rocío; Alcarranza Saucedo, Manuel; Khiar, Noureddine; Fernández Fernández, Inmaculada (Wiley Online Library, 2018-03)An efficient sulfinamide/olefin based chiral ligand, MetSulfolefin, has been developed for the enantioselective rhodium-catalysed ...
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Artículo
Benzothiazole Derivatives Endowed with Antiproliferative Activity in Paraganglioma and Pancreatic Cancer Cells: Structure–Activity Relationship Studies and Target Prediction Analysis
Amoroso, Rosa; De Lellis, Laura; Florio, Rosalba; Moreno Rodríguez, Nazaret; Agamennone, Mariangela; De Filippis, Barbara; Giampietro, Letizia; Maccallini, Cristina; Fernández Fernández, Inmaculada; Recio Jiménez, Rocío; Cama, Alessandro; Fantacuzzi, Marialuigia; Ammazzalorso, Alessandra (Multidisciplinary Digital Publishing Institute (MDPI), 2022)The antiproliferative effects played by benzothiazoles in different cancers have aroused the interest for these molecules ...
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Biological Evaluation of Carbohydrate-based Aprepitant Analogs for Neuroblastoma Treatment
Valdivia Giménez, Victoria Esther; Recio Jiménez, Rocío; Lerena, Patricia; Pozo, Esther; Serrano, Rosario; Calero, Raúl; Pintado, Cristina; Pernia Leal, Manuel; Moreno Rodríguez, Nazaret; Organero, Juan Ángel; Khiar, Noureddine; Fernández Fernández, Inmaculada (Elsevier, 2024)Different studies using Aprepitant, a NK1R antagonist currently used as a clinical drug for treating chemotherapy-related ...
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Artículo
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity
Recio Jiménez, Rocío; Lerena Pérez, Patricia; Pozo Torres, Esther; Calderón Montaño, José Manuel; Burgos Morón, Estefanía; López Lázaro, Miguel; Valdivia Giménez, Victoria Esther; Pernia Leal, Manuel; Mouillac, Bernard; Organero, Juan Ángel; Khiar, Noureddine; Fernández Fernández, Inmaculada (American Chemical Society, 2021)NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment ...
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Artículo
Chiral sulfur derivatives in the allylation of acyl hydrazones: C 2-symmetric bis-sulfinamides as enhanced chiral organic promoters
Fernández Fernández, Inmaculada; Alcudia Cruz, Ana; Gori, Beatrice; Valdivia Giménez, Victoria Esther; Recio Jiménez, Rocío; García, María Victoria; Khiar, Noureddine (Royal Society of Chemistry, 2010-10)Monosulfinamides and C2-symmetric bis-sulfinamides are convenient neutral chiral promoters in the allylation of acyl ...
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Artículo
Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification
Recio Jiménez, Rocío; Vengut-Climent, Empar; Mouillac, Bernard; Orcel, Hélène; López Lázaro, Miguel; Calderón Montaño, José Manuel; Álvarez González, Eleuterio; Khiar, Noureddine; Fernández Fernández, Inmaculada (Elsevier, 2017)A library of 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyrans has been synthesized as a new family of non-peptide ...
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DMAP-Catalysed Sulfinylation of Diacetone-D-Glucose: Improved Method for the Synthesis of Enantiopure tert-Butyl Sulfoxides and tert-Butanesulfinamide
Chelouan, Ahmed; Recio Jiménez, Rocío; Alcudia Cruz, Ana; Khiar, Noureddine; Fernández Fernández, Inmaculada (Wiley Online Library, 2014-11)An improved method for the tert-butanesulfinylation of diacetone glucose with tert-butanesulfinyl chloride is reported. ...
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Artículo
Enantioselective synthesis of 4-amino-3,4-dihydrocoumarins and their non-cyclic hydroxyester precursors: Biological evaluation for the treatment of glioblastoma multiforme
Borrego Sánchez de la Cuesta, Lorenzo Gabriel; Recio Jiménez, Rocío; Moreno Rodríguez, Nazaret; Chelouan, Ahmed; Álvarez, Eleuterio; Sánchez Coronilla, Antonio; Caro Salazar, Carlos; Pearson, John R.; García-Martín, María Luisa; Khiar, Noureddine; Fernández Fernández, Inmaculada (Elsevier, 2022)The stereoselective addition of ethyl acetate enolate to the C═N bond of N-tert-butylsulfinylimines has been investigated ...
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Artículo
Immunomodulatory Effects of (R)-Sulforaphane on LPS-Activated Murine Immune Cells: Molecular Signaling Pathways and Epigenetic Changes in Histone Markers
Alcarranza Saucedo, Manuel; Villegas Lama, Isabel; Muñoz García, Rocío; Recio Jiménez, Rocío; Fernández Fernández, Inmaculada; Alarcón de la Lastra Romero, Catalina (Multidisciplinary Digital Publishing Institute (MDPI), 2022)The aim of this study was to explore the immunomodulatory effects of the natural enantiomer (R)-Sulforaphane (SFN) and the ...
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Artículo
N -Isopropylsulfinylimines vs. N-tert -butylsulfinylimines in the stereoselective synthesis of sterically hindered amines: An improved synthesis of enantiopure (R)- And (S)-rimantadine and the trifluoromethylated analogues
Moreno Rodríguez, Nazaret; Recio Jiménez, Rocío; Valdivia Giménez, Victoria Esther; Khiar, Noureddine; Fernández Fernández, Inmaculada (Royal Society of Chemistry, 2019-11-04)An improved fully stereoselective synthesis of both enantiomers of rimantadine and its trifluoromethylated analogues has ...
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Artículo
NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins
Recio Jiménez, Rocío; Elhalem, Eleonora; Benito, Juan M.; Fernández Fernández, Inmaculada; Khiar, Noureddine (Elsevier, 2018)Sulforaphane (SFN), a phytochemical isolated from broccoli, is an important antitumoral compound with additional beneficial ...
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Artículo
Pseudo enantiomeric mixed s/p ligands derived from carbohydrates for the 1,4-addition of phenyl boronic acid to cyclohexenone
Valdivia Giménez, Victoria Esther; Bilbao Bustinza, Nerea; Moya, Juan Francisco; Rosales Barrios, C.; Salvador, Álvaro; Recio Jiménez, Rocío; Fernández Fernández, Inmaculada; Khiar, Noureddine (Royal Society of Chemistry, 2016)The application of phosphinite-thioglycosides and phosphine-thioglycosides ligands in the Rh(I)-catalyzed 1,4-addition of ...
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(R)-8-Methylsulfinyloctyl isothiocyanate from Nasturtium officinale inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved
Alcarranza Saucedo, Manuel; Villegas Lama, Isabel; Recio Jiménez, Rocío; Muñoz García, Rocío; Fernández Fernández, Inmaculada; Alarcón de la Lastra Romero, Catalina (Royal Society of Chemistry, 2023-07-20)The aim of this study was to develop an optimal synthetic route to obtain natural (R)-8-methylsulfinyloctyl isothiocyanate ...
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Síntesis estereoselectiva de una nueva familia de beta -aminoésteres de interés farmacológico como inhibidores potenciales de la agregación plaquetaria.
Borrego Sánchez de la Cuesta, Lorenzo Gabriel; Recio Jiménez, Rocío; Chelouan, Ahmed; Khiar, Noureddine; Fernández Fernández, Inmaculada (Universidad pablo de Olavide, 2015)Motivación: La utilización de compuestos estereoquímicamente puros presenta numerosas ventajas frente al uso de racematos ...
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Steric Tuning of Sulfinamide/Sulfoxides as Chiral Ligands with C1, Pseudo-meso, and Pseudo‑C2 Symmetries: Application in Rhodium(I)-Mediated Arylation
Borrego Sánchez de la Cuesta, Lorenzo Gabriel; Recio Jiménez, Rocío; Álvarez González, Eleuterio; Sánchez Coronilla, Antonio; Khiar, Noureddine; Fernández Fernández, Inmaculada (ACS, 2019-07-31)A new family of sulfinamide/sulfoxide derivatives was synthesized as chiral bidentate ligands by stereoselective additions ...
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Studies on the diastereoselective oxidation of 1-thio-β-D-glucopyranosides: synthesis of the usually less favoured RS sulfoxide as a single diastereoisomer
Moya López, Juan Francisco; Elhalem, Eleonora; Recio Jiménez, Rocío; Álvarez González, Eleuterio; Fernández Fernández, Inmaculada; Khiar, Noureddine (Royal Society of Chemistry, 2015)A detailed study on the diastereoselective oxidation of 1-thio-β-D-glucopyranosides is reported. It has been shown that ...
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Artículo
Sulfinamide Phosphinates as Chiral Catalysts for the Enantioselective Organocatalytic Reduction of Imines
Chelouan, Ahmed; Recio Jiménez, Rocío; Borrego Sánchez de la Cuesta, Lorenzo Gabriel; Álvarez, Eleuterio; Khiar, Noureddine; Fernández Fernández, Inmaculada (American Chemical Society, 2016-07)A new type of chiral sulfinamide phosphinate catalysts with up to three stereogenic centers, readily accessible from ...
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Synthesis and characterization of enantiopure chiral NH2/SO palladium complexes
Moreno Rodríguez, Nazaret; Borrego Sánchez de la Cuesta, Lorenzo Gabriel; Recio Jiménez, Rocío; Valdivia Giménez, Victoria Esther; Nicasio Jaramillo, María del Carmen; Álvarez González, Eleuterio; Khiar, Noureddine; Fernández Fernández, Inmaculada (Royal Society of Chemistry, 2023)A series of enantiopure chiral NH2/SO palladium complexes have been synthesised with high yields by treating the corresponding ...