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Mostrando ítems 1-10 de 19
Artículo
Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition
(Wiley-Blackwell, 2009)
Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression of several age-related neurodegenerative disorders. However, the mechanisms linking proteasome ...
Artículo
Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density
(Elsevier, 2011)
To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that ...
Tesis Doctoral
Posible papel diferencial de la autofagia en respuesta al estrés proteico en microglía y neuronas
(2022-03-18)
En esta tesis doctoral hemos afrontado el estudio de mecanismos implicados en el mantenimiento de la proteostasis en dos tipos diferentes de células del sistema nervioso: microglía y neuronas. Para ello, se ha usado un ...
Artículo
Learning improvement after PI3K activation correlates with de novo formation of functional small spines
(Frontiers Media S.A., 2014)
PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes. In this report, we show that ...
Tesis Doctoral
Artículo
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
(Springer, 2012)
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus ...
Artículo
Proteostasis Dysfunction in Aged Mammalian Cells. The Stressful Role of Inflammation
(Frontiers Media S.A., 2021)
Aging is a biological and multifactorial process characterized by a progressive and irreversible deterioration of the physiological functions leading to a progressive increase in morbidity. In the next decades, the world ...
Artículo
Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation
(Nature Publishing Group, 2017)
Proteostasis alteration and neuroinflammation are typical features of normal aging. We have previously shown that neuroinflammation alters cellular proteostasis through immunoproteasome induction, leading to a transient ...