Buscar
Mostrando ítems 21-30 de 67
Artículo
Sam68 Mediates the Activation of Insulin and Leptin Signalling in Breast Cancer Cells
(Public Library Science, 2016)
Obesity is a well-known risk factor for breast cancer development in postmenopausal women. High insulin and leptin levels seem to have a role modulating the growth of these tumours. Sam68 is an RNA-binding protein with ...
Tesis Doctoral
Estudio antropológico de las nuevas poblaciones de Sierra Morena comparación con la población andaluza autóctona y germánica, mediante el estudio del polimorfismo HLA de clase I
(2010)
Hemos estudiado los antígenos HLA de Clase I, de 50 familias de Andalucía y otras 50 procedentes de las nuevas poblaciones de Sierra Morena (La Carolina, Guarroman, Navas de Tolosa, Carboneros y Acebuchal), en las que se ...
Artículo
Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation
(Elsevier, 2010)
Mast cells take part of armamentarium immunologic for host defense against parasitic and bacterial infections. They are derived from bone marrow progenitors and can be activated by immunological and chemical stimuli in ...
Artículo
Oxidative stress influence on renal dysfunction in patients with obstructive jaundice: A case and control prospective study
(Elsevier, 2015-12-29)
Obstructive Jaundice (OJ) is associated with a significant risk of developing acute renal failure (ARF). The involvement of oxidative stress in the development of cholestasis has been demonstrated in different experimental ...
Artículo
Dietary fatty acids on aortic root calcification in mice with metabolic syndrome
(Royal Society of Chemistry, 2017)
Metabolic syndrome (MetS) is associated with obesity, dyslipidemia, type 2 diabetes, and chronic low-grade inflammation. The aim of this study was to determine the role of high-fat low-cholesterol diets (HFLCDs) rich in ...
Artículo
Newborn Screening for Primary T- and B-Cell Immune Deficiencies—A Prospective Study in Andalucía
(MDPI, 2017)
Background: Quantification of T-cell-receptor-excision circles (TRECs) and kappa-deleting-recombination-excision circles (KRECs) from dried blood spots (DBS) allows detection of neonates with severe T-cell and/or B-cell ...
Tesis Doctoral
Estudio de variantes genéticas y análisis epigenético de loci asociados a esclerosis múltiple
(2014-07-10)
La Esclerosis Múltiple es una enfermedad autoinmune y neurodegenerativa de patogenia compleja, en la que en su mecanismo de susceptibilidad se barajan fenómenos multifactoriales genéticos y ambientales. El haplotipo ...
Tesis Doctoral
Epigenética de los procesos de autorrenovación, pluripotencialidad y diferenciación de las células troncales
(2010)
El objetivo general de esta tesis ha sido definir la importancia que poseen los procesos epigenéticos sobre el mantenimiento del estado pluripotente y el proceso de diferenciación de las células troncales embrionarias. ...
Artículo
Artículo
PGC-1alfa controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
(Impact Journals LLC, 2015-04-09)
Due to its role in regulation of mitochondrial function, PGC1α is emerging as an important player in ageing and neurodegenerative disorders. PGC1α exerts its neuroprotective effects by promoting mitochondrial biogenesis ...