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Mostrando ítems 1-10 de 24
Artículo
A novel potential nanophototherapeutic based on the assembly of an amphiphilic cationic ß-cyclodextrin and an anionic porphyrin
(John Wiley & Sons, 2017)
The development of cyclodextrin nanoassemblies as useful carriers for photosensitizer drugs (PS) delivery in biological environment is a topic of increasing interest. In this paper, we present a spectroscopic investigation ...
Artículo
Synthesis and reactivity studies of cationic Ir(III) alkylidines. α-hydride abstraction reactions
(Sociedad Química de México, 2017)
The chemistry of late transition metal alkylidenes [M=CR2], where R is H a hydrocarbyl group, have attracted widespread attention although mainly with reference to complexes of metals in low oxidation state. We focus in ...
Artículo
Asymmetric organocatalytic synthesis of tertiary azomethyl alcohols: key intermediates towards azoxy compounds and α-hydroxy-β-amino esters
(Royal Society of Chemistry (Great Britain), 2017)
A series of peracylated glycosamine-derived thioureas have been synthesized and their behavior as bifunctional organocatalysts has been tested in the enantioselective nucleophilic addition of formaldehyde tert-butyl hydrazone ...
Artículo
LPS promotes Th2 dependent sensitisation leading to anaphylaxis in a Pru p 3 mouse model
(Nature Publishing Group, 2017-01-13)
Pru p 3 is the major peach allergen in the Mediterranean area. It frequently elicits severe reactions, limiting its study in humans, raising the need for animal models to investigate the immunological mechanisms involved. ...
Artículo
Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection
(Future Medicine Ltd., 2017)
Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient siRNA transfection vector. Materials & methods: siRNA protection from degradation by RNAses, transfection ...
Artículo
The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study
(2017)
The vision of multivalency as a strategy limited to achieve affinity enhancements between a protein receptor and its putative sugar ligand (glycotope) has proven too simplistic. On the one hand, binding of a glycotope in ...
Artículo
Biophysics and protein corona analysis of Janus cyclodextrin-DNA nanocomplexes. Efficient cellular transfection on cancer cells
(Elsevier, 2017)
The self-assembling processes underlining the capabilities of facially differentiated (¿Janus¿) polycationic amphiphilic cyclodextrins (paCDs) as non-viral gene nanocarriers have been investigated by a pluridisciplinary ...
Artículo
Following palladium catalyzed methoxycarbonylation by hyperpolarized NMR spectroscopy: a parahydrogen based investigation
(Royal Society of Chemistry, 2017)
Pd(OTf)2(bcope) is shown to react in methanol solution with diphenylacetylene, carbon monoxide and hydrogen to produce the methoxy-carbonylation product methyl 2,3 diphenyl acrylate alongside cis- and trans-stilbene. In ...
Artículo
Synthesis of β-galactosylamides as Ligands of the Peanut Lectin. Insights into the Recognition Process
(Elsevier, 2017)
The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived from L-tartaric anhydride is reported. Reference compounds devoid of hydroxyl groups in the linker were ...
Artículo
Broad Scope Synthesis of Ester Precursors of Nonfunctionalized Chiral Alcohols Based on the Asymmetric Hydrogenation of α,β-Dialkyl-, α,β-Diaryl-, and α-Alkyl-β-aryl-vinyl Esters
(American Chemical Society, 2017)
The catalytic asymmetric hydrogenation of trisubstituted enol esters using Rh catalysts bearing chiral phosphine-phosphite ligands (P-OP) has been studied. Substrates covered comprise α,β-dialkyl, α-alkyl-β-aryl, and ...