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Mostrando ítems 1-9 de 9
Artículo
Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model
(Nature, 2019-02-11)
An effective specific immunotherapy should contain elements to generate specific recognition (T-cell peptides) and to modulate the immunological response towards a Th1/Treg pattern by enhancing dendritic cells (DCs). We ...
Artículo
LPS promotes Th2 dependent sensitisation leading to anaphylaxis in a Pru p 3 mouse model
(Nature Publishing Group, 2017-01-13)
Pru p 3 is the major peach allergen in the Mediterranean area. It frequently elicits severe reactions, limiting its study in humans, raising the need for animal models to investigate the immunological mechanisms involved. ...
Artículo
Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection
(Nature Publishing Group, 2012)
Ligand polyvalency is a powerful modulator of protein–receptor interactions. Host–pathogen infection interactions are often mediated by glycan ligand–protein interactions, yet its interrogation with very high copy number ...
Artículo
Cyclooctyne [60]fullerene hexakis adducts: a globular scaffold for copper-free click chemistry
(Royal Society of Chemistry, 2016)
The synthesis of a new highly symmetric hexakis adduct of C60 appended with 12 cyclooctyne moieties has been carried out. This compound has been used for the copper-free strain-promoted cycloaddition reaction to a series ...
Artículo
Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection
(Nature Publishing Group, 2016)
The use of multivalent carbohydrate compounds to block cell-surface lectin receptors is a promising strategy to inhibit the entry of pathogens into cells and could lead to the discovery of novel antiviral agents. One of ...
Artículo
Unique DC-SIGN clustering activity of a small glycomimetic: a lesson for ligand design
(American Chemical Society, 2014)
DC-SIGN is a dendritic cell-specific C-type lectin receptor that recognizes highly glycosylated ligands expressed on the surface of various pathogens. This receptor plays an important role in the early stages of many viral ...
Artículo
NMR studies on carbohydrate interactions with DC-SIGN towards a quantitative STD analysis
(De Gruyter, 2013)
The recent introduction of saturation transfer difference (STD) NMR has increased the tools for the study of protein–carbohydrate complexes. This is useful when it is combined with transfer nuclear Overhauser enhancement ...
Artículo
Detection and Quantitative Analysis of Two Independent Binding Modes of a Small Ligand Responsible for DC-SIGN Clustering
(Royal Society of Chemistry, 2015)
DC-SIGN (dendritic cell-specific ICAM-3 grabbing non-integrin) is a C-type lectin receptor (CLR) present, mainly in dendritic cells (DCs), as one of the major pattern recognition receptors (PRRs). This receptor has a ...
Artículo
Docking, synthesis, and NMR studies of mannosyl trisaccharide ligands for DC-SIGN lectin
(Royal Society of Chemistry (Great Britain), 2008)
DC-SIGN, a lectin, which presents at the surface of immature dendritic cells, constitutes nowadays a promising target for the design of new antiviral drugs. This lectin recognizes highly glycosylated proteins present at ...