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Artículo
Synthesis, structure and midkine binding of chondroitin sulfate oligosaccharide analogues
(Royal Society of Chemistry, 2021)
The preparation of chondroitin sulfate (CS) oligosaccharide mimetics, more easily synthesized than natural sequences, is a highly interesting task because these compounds pave the way for modulation of the biological ...
Artículo
Synthesis of Chondroitin Sulfate Oligosaccharides Using N-(Tetrachlorophthaloyl)- and N-(Trifluoroacetyl)galactosamine Building Blocks
(Wiley-Blackwell, 2014)
We have explored synthetic routes for the preparation of chondroitin sulfate (CS) oligosaccharides based on the use of N-tetrachlorophthaloyl- (N-TCP) and N-trifluoroacetyl-substituted (N-TFA) galactosamine building blocks. ...
Artículo
Synthesis of chondroitin/dermatan sulfate-like oligosaccharides and evaluation of their protein affinity by fluorescence polarization
(Royal Society of Chemistry (Great Britain), 2013)
Here, we present a novel approach for the chemical synthesis of chondroitin and dermatan sulfate oligosaccharides. A key point of this strategy is the preparation and use of an N-trifluoroacetyl galactosamine building block ...
Artículo
Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach
(Elsevier, 2014)
The synthesis of hyaluronic acid oligomers (tri- and tetrasaccharide) is described. We have followed a pre-glycosylation oxidation strategy. Glucuronic acid units were directly employed in coupling reactions with suitably ...
Artículo
Interactions between a Heparin Trisaccharide Library and FGF-1 Analyzed by NMR Methods
(MDPI, 2017-06-17)
FGF-1 is a potent mitogen that, by interacting simultaneously with Heparan Sulfate Glycosaminoglycan HSGAG and the extracellular domains of its membrane receptor (FGFR), generates an intracellular signal that finally leads ...