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Mostrando ítems 1-10 de 25
Artículo
Post-Translational Modifications of Cytochrome c in Cell Life and Disease
(MDPI, 2020)
Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including neurodegenerative diseases, cardiovascular diseases, and various types of cancer. In mitochondrial ...
Artículo
ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs
(Springer, 2021)
Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Using various biochemical approaches, we have identified members of the CNNM family as direct interacting partners of ADP-ribosylation ...
Artículo
Structural insights into the intracellular region of the human magnesium transport mediator CNNM4
(Multidisciplinary Digital Publishing Institute (MDPI), 2019)
The four member family of “Cyclin and Cystathionine β-synthase (CBS) domain divalent metal cation transport mediators”, CNNMs, are the least-studied mammalian magnesium transport mediators. CNNM4 is abundant in the brain ...
Artículo
Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria
(National Academy of Sciences, 2018)
Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective insulin treatment, but how such posttranslational modification affects mitochondrial metabolism is ...
Artículo
Nicotinamide N-methyltransferase (NNMT) regulates the glucocorticoid signaling pathway during the early phase of adipogenesis
(Springer Nature, 2023-05-22)
Obesity is associated with adipose tissue dysfunction through the differentiation and expansion of pre-adipocytes to adipocytes (hyperplasia) and/or increases in size of pre-existing adipocytes (hypertrophy). A cascade of ...
Artículo
Exploring protein phosphorylation by combining computational approaches and biochemical methods
(Elsevier, 2020)
Post-translational modifications of proteins expand their functional diversity, regulating the response of cells to a variety of stimuli. Among these modifications, phosphorylation is the most ubiquitous and plays a prominent ...
Artículo
Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
(Elsevier, 2023)
Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed developmentally downregulated protein 8 (NEDD8). Here, we show that neddylation in mouse liver is ...
Artículo
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer
(Elsevier, 2019)
BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular ...
Artículo
Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c
(Oxford University Press, 2017)
Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the DNA repair process have focused on yeast and mammals, in which histone chaperone-mediated nucleosome ...
Artículo
Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48
(National Academy of Sciences, 2017)
Regulation of mitochondrial activity allows cells to adapt to changing conditions and to control oxidative stress, and its dysfunction can lead to hypoxia-dependent pathologies such as ischemia and cancer. Although ...