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Tesis Doctoral
Dynamization strategies for the atroposelective synthesis of (hetero)biaryls
(2019-07-22)
The central objective in this PhD thesis has been the development of asymmetric catalysis methodologies for the atroposelective synthesis of (hetero)biaryls through dynamization strategies. These methodologies comprise ...
Artículo
Role of surface tryptophan for peroxidase oxidation of nonphenolic lignin
(BMC (part of Springer Nature), 2016)
Background: Despite claims as key enzymes in enzymatic delignification, very scarce information on the reaction rates between the ligninolytic versatile peroxidase (VP) and lignin peroxidase (LiP) and the lignin polymer ...
Artículo
Asymmetric Organocatalytic Synthesis of Fluorinated β-Hydroxy Diazenes
(Wiley-Blackwell, 2019)
The nucleophilic addition of formaldehyde tert-butyl hydrazone to fluoromethyl ketones provides a valuable tool for the synthesis of highly functionalized β-hydroxy β-tri- and difluoromethyl diazenes. Excellent reactivities ...
Artículo
Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars
(Elsevier, 2019)
The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives and tri- or hexavalent alkynyl scaffolds is reported. The new multimeric compounds, together ...
Tesis Doctoral
Sistemas dendríticos para la presentación multivalente de glicosaminoglicanos
(2019-04-26)
Los glicosaminoglicanos (GAGs) son polisacáridos altamente sulfatados y heterogéneos que participan en un gran número de procesos biológicos por interacción con determinadas proteínas. Con el fin de conocer el ...
Artículo
Synthesis of β-galactosylamides as Ligands of the Peanut Lectin. Insights into the Recognition Process
(Elsevier, 2017)
The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived from L-tartaric anhydride is reported. Reference compounds devoid of hydroxyl groups in the linker were ...
Artículo
Stereoselective enzymatic reduction of 1,4-diaryl-1,4-diones to the corresponding diols employing alcohol dehydrogenases
(MDPI, 2018)
Due to the steric hindrance of the starting prochiral ketones, the preparation of chiral 1,4-diaryl-1,4-diols through the asymmetric hydrogen transfer reaction has been mainly restricted to the use of metal-based catalysts, ...
Tesis Doctoral
Carbenos n-heterocíclicos fusionados en sistemas de biarilo: síntesis, estructura, coordinación y aplicaciones en catálisis asimétrica
(2016-12-19)
A lo largo de esta Tesis Doctoral se ha llevado a cabo el diseño y síntesis de nuevas familias de azolios quirales precursores de carbenos N-heterocíclicos (CNHs) basados en Ndialquilamino- imidazo[1,5-a]piridin-3-ilidenos ...
Artículo
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells
(MDPI, 2019)
With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance ...
Artículo
Azabicyclic vinyl sulfones for residue-specific dual protein labelling
(Royal Society of Chemistry, 2019)
We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective ...