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Mostrando ítems 151-160 de 441
Artículo
Ginsenosides act as positive modulators of P2X4 receptors
(American Society for Pharmacology and Experimental Therapeutics (ASPET), 2019)
We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting as positive allosteric modulators on P2X receptors. ATP-induced responses were measured in stable cell lines overexpressing human ...
Artículo
Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7
(Nature Research (part of Springer Nature): Fully open access journals, 2019)
P2X7 receptors are important in the regulation of inflammatory responses and immune responses to intracellular pathogens such as Mycobacterium tuberculosis and Toxoplasma gondii. enhancement of P2X7 receptor responses may ...
Artículo
Positive impact of natural deep eutectic solvents on the biocatalytic performance of 5-hydroxymethyl-furfural oxidase
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Deep eutectic solvents (DESs) have been applied as cosolvents in various biocatalytic processes during recent years. However, their use in combination with redox enzymes has been limited. In this study, we have explored ...
Tesis Doctoral
Diseño de ligandos mixtos carbeno N-heterocíclico (CNH)/tioéter y aplicaciones en catálisis enantioselectiva
(2012-01-01)
Uno de los aspectos más importantes de la Química como ciencia aplicada es la de poder sintetizar moléculas que puedan ser de utilidad en la vida diaria. E n la mayoría de los procesos fisiológicos hay una serie de ...
Artículo
Visible and NIR Light Assistance of the N2 Reduction to NH3 Catalyzed by Cs-promoted Ru Nanoparticles Supported on Strontium Titanate
(American Chemical Society, 2022)
NH3 production accounts for more than 1% of the total CO2 emissions and is considered one of the most energy-intensive industrial processes currently (T > 400 °C and P > 80 bars). The development of atmospheric-pressure ...
Tesis Doctoral
DYKAT and desymmetrization strategies for the synthesis of axially chiral heterobiaryls
(2020-01-31)
The main objective of this PhD thesis is the development of new methodologies for the synthesis of axially chiral heterobiaryls through asymmetric functionalization of this type of systems. In this regard, the approaches ...
Tesis Doctoral
Artículo
Atroposelective transformation of axially chiral (hetero)biaryls. From desymmetrization to modern resolution strategies
(Royal Society of Chemistry, 2021)
This tutorial review provides a systematic overview of the available methodologies for the atroposelective transformation of (heterobiaryl)biaryl precursors toward the synthesis of enantiomerically enriched products and ...
Artículo
N-Heterotricyclic Cationic Carbene Ligands. Synthesis, Reactivity and Coordination Chemistry
(Royal Society of Chemistry, 2018)
The direct dialkylation of triazolo[4,3-b]isoquinolin-3-ylidene structures readily affords dicationic N-heterotricyclic azolium salts. These are suitable starting materials for the synthesis of transition metal complexes ...
Tesis Doctoral
Ligandos de nueva generación basados en hidrazonas para aplicaciones en catálisis asimétrica
(2016-04-28)
La creciente demanda de compuestos enantioméricamente puros para su uso como fármacos, aromas, fragancias, productos agroquímicos y precursores de materiales poliméricos ha impulsado el desarrollo espectacular de la síntesis ...