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Artículo
Securin Is a Target of the UV Response Pathway in Mammalian Cells
(2004)
All eukaryotic cells possess elaborate mechanisms to protect genome integrity and ensure survival after DNA damage, ceasing proliferation and granting time for DNA repair. Securin is an inhibitory protein that is bound to ...
Artículo
Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase
(2006)
Sister chromatid segregation is triggered at the metaphase-to-anaphase transition by the activation of the protease separase. For most of the cell cycle, separase activity is kept in check by its association with the ...
Artículo
UV-induced degradation of securin is mediated by SKP1-CUL1-βTrCP E3 ubiquitin ligase
(Company of Biologists, 2008)
Securin is a chaperone protein with bifunctional properties. It binds to separase to inhibit premature sister chromatid separation until the onset of anaphase, and it also takes part in cell-cycle arrest after UV irradiation. ...