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Artículo
Identification and characterization of a new porin gene of Klebsiella pneumoniae: Its role in β-lactam antibiotic resistance
(American Society for Microbiology, 1999)
Klebsiella pneumoniae porin genes were analyzed to detect mutations accounting for the porin deficiency observed in many β-lactam-resistant strains. PCR and Southern blot analysis revealed the existence of a third porin ...
Artículo
In vivo selection of porin-deficient mutants of Klebsiella pneumoniae with increased resistance to cefoxitin and expanded-spectrum cephalosporins
(American Society for Microbiology, 1996-02-01)
Four Klebsiella pneumoniae isolates (LB1, LB2, LB3, and LB4) with increased antimicrobial resistance were obtained from the same patient. The four isolates were indistinguishable in biotype, plasmid content, lipopolysaccharide, ...
Artículo
Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes
(American Society for Microbiology, 1999-01-01)
We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to ...
Artículo
Role of Klebsiella pneumoniae LamB porin in antimicrobial resistance
(American Society for Microbiology, 2003-10-01)
To investigate the contribution of LamB in Klebsiella pneumoniae antimicrobial resistance, we determined the MICs of various antibiotics and the frequency of mutation to increased cefoxitin or meropenem resistance of the ...