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Artículo
Patterns of expression and translocation of the ubiquitin ligase SlrP in Salmonella enterica serovar typhimurium.
(American Society for Microbiology, 2014)
SlrP is an E3 ubiquitin ligase that can be translocated into eukaryotic host cells by the two type III secretion systems that are expressed by Salmonella enterica serovar Typhimurium and are encoded in Salmonella pathogenicity ...
Tesis Doctoral
The role of RNA Polymerase II-dependent transcription elongation in the cross-talk between mRNA synthesis and decay.
(2018-02-06)
The main molecule in gene expression is messenger RNA (mRNA) which transfers the information contained in genes in the nucleus to the cytoplasm where it is translated into proteins that carry out cellular functions. mRNA ...
Artículo
The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins
(EMBO Press, 2019-07-24)
Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how cells do counteract spontaneous DNA–RNA hybrids, here we screen an siRNA library covering 240 human ...
Artículo
Artículo
Prognostic value of CtIP/RBBP8 expression in breast cancer
(Wiley Open Access, 2013)
CtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination and the G1 and G2 checkpoints. Its multiple roles are controlled by its interaction with several ...
Artículo
A Live Salmonella Vaccine Delivering PcrV through the Type III Secretion System Protects against Pseudomonas aeruginosa
(American Society for Microbiology, 2019)
Pseudomonas aeruginosa is a common Gram-negative opportunistic pathogen that is intrinsically resistant to a wide range of antibiotics. The development of a broadly protective vaccine against P. aeruginosa remains a major ...
Artículo
Artículo
Final pre-40s maturation depends on the functional integrity of the 60s subunit ribosomal protein l3
(Public Library of Science, 2014)
Ribosomal protein L3 is an evolutionarily conserved protein that participates in the assembly of early pre-60S particles. We report that the rpl3[W255C] allele, which affects the affinity and function of translation ...
Artículo
What causes an RNA-DNA hybrid to compromise genome integrity?
(Elsevier, 2019)
Transcription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced by transcription is mediated by R-loops, non-B DNA structures that normally form by the re-annealing ...
Artículo
Use of chitin and chitosan to produce new chitooligosaccharides by chitinase Chit42: enzymatic activity and structural basis of protein specificity
(BioMed Central, 2018)
Background Chitinases are ubiquitous enzymes that have gained a recent biotechnological attention due to their ability to transform biological waste from chitin into valued chito-oligomers with wide agricultural, ...