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Artículo
Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain
(Impact Journals, 2015)
Otto Warburg observed that cancer cells derived their energy from aerobic glycolysis by converting glucose to lactate. This mechanism is in opposition to the higher energy requirements of cancer cells because oxidative ...
Artículo
The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment
(Impact Journals, 2017)
Inflammation is a complex defensive response activated after various harmful stimuli allowing the clearance of damaged cells and initiating healing and regenerative processes. Chronic, or pathological, inflammation is also ...
Artículo
NUMB and NUMBL differences in gene regulation
(Impact Journals, 2018)
NUMB, and its close homologue NUMBL, behave as tumor suppressor genes by regulating the Notch pathway. The downregulation of these genes in tumors is common, allowing aberrant Notch pathway activation and tumor progression. ...