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Papel de la actividad de la proteína quinasa A(PKA) en el mantenimiento estructural y biogénesis del complejo de Golgi [Doctoral Thesis]
(2007)
El complejo de Golgi es un lugar de concentración preferente de PKA en células mamíferos y su actividad modula diferentes pasos del tráfico intracelular. Dado que la arquitectura del orgánulo depende del balance entre ...
Análisis de la función y la regulación de ArfGAP1 [Doctoral Thesis]
(2015-09-25)
Una de las características más significativas de la célula eucariota es el incesante tráfico vesicular que acontece entre sus orgánulos. A pesar de ello, y con el fin de mantener su propia identidad, cada compartimento ...
Protein kinase A activity is required for the budding of constitutive transport vesicles from the trans-Golgi network [Article]
(PNAS USA, 1997)
We have examined the role played by protein kinase A (PKA) in vesicle-mediated protein transport from the trans-Golgi network (TGN) to the cell surface. In vivo this transport step was inhibited by inhibitors of PKA ...
Precursors of chondroitin sulfate proteoglycan are segregated within a subcompartment of the chondrocyte endoplasmic reticulum [Article]
(Rockefeller University Press, 1989)
Immunocytochemical methods were used at the levels of light and electron microscopy to examine the intracellular compartments of chondrocytes involved in extracellular matrix biosynthesis. The results of our studies provide ...
Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II [Article]
(Rockefeller University Press, 1993)
alpha-mannosidases I and II (Man I and II) are resident enzymes of the Golgi complex involved in oligosaccharide processing during N-linked glycoprotein biosynthesis that are widely considered to be markers of the cis- and ...
Protein kinase A activity is required for the budding of constitutive transport vesicles from the trans-Golgi network [Article]
(Academia Nacional de Ciencias de Estados Unidos, 1997)
We have examined the role played by protein kinase A (PKA) in vesicle-mediated protein transport from the trans-Golgi network (TGN) to the cell surface. In vivo this transport step was inhibited by inhibitors of PKA catalytic ...
Trimeric G proteins modulate the dynamic interaction of PKAII with the Golgi complex [Article]
(The Company of Biologists Ltd, 1999)
The Golgi complex represents a major subcellular location of protein kinase A (PKA) concentration in mammalian cells where it has been previously shown to be involved in vesicle-mediated protein transport processes. We ...
The retrieval function of the KDEL receptor requires PKA phosphorylation of its C-terminus [Article]
(The American Society for Cell Biology, 2004)
The KDEL receptor is a Golgi/intermediate compartment-located integral membrane protein that carries out the retrieval of escaped ER proteins bearing a C-terminal KDEL sequence. This occurs throughout retrograde traffic ...
Biosíntesis celular de proteoglicanos por los condrocitos epifisarios [Doctoral Thesis]
(1985)
Mediante métodos citosmímicos (enrimas y lectinas marcadas con oro coloidal) se ha estudiado las reacciones de flicosilación en diferentes compartimentos celulares de condrocitos durante la biosíntesis de proteoflícenos ...