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Mostrando ítems 1-6 de 6
Artículo
The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
(Oxford University Press, 2014)
Decitabine (5-aza-21-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid Leukemia (AML). Its mechanism of action is thought to involve reactivation of genes implicated in ...
Artículo
Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast
(Company of Biologists Ltd, 2014)
Lipids synthesized at the endoplasmic reticulum (ER) are delivered to the Golgi by vesicular and non-vesicular pathways. ER-to-Golgi transport is crucial for maintaining the different membrane lipid composition and identities ...
Artículo
ATM specifically mediates repair of double-strand breaks with blocked DNA ends
(Nature Publishing Group, 2014)
Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator ...
Artículo
Biological activity and redistribution of nucleolar proteins of two different cell lines treated with cis-dichloro-1,2-propylenediamine-N,N,N',N'-tetraacetato ruthenium (III) (RAP)
(National Institute of Science Communication and Information Resources, 2014)
The interaction of a newly synthesized antitumor complex cis-dichloro-1,2-propylenediamine-N,N,N',N'-tetraacetato ruthenium (III) (RAP) with DNA was investigated in vitro through a number of techniques including comet ...
Artículo
Biotensegrity of the Extracellular Matrix: Physiology, Dynamic Mechanical Balance, and Implications in Oncology and Mechanotherapy
(Frontiers Media, 2014)
Cells have the capacity to convert mechanical stimuli into chemical changes. This process is based on the tensegrity principle, a mechanism of tensional integrity. To date, this principle has been demonstrated to act in ...
Patente. Invención
Método para obtener información útil para el diagnóstico de enfermedades neuromusculares
(Oficina Española de Patentes y Marcas (OEPM), 2014-04-15)
Método para obtener información útil para el diagnóstico de enfermedades neuromusculares. Procedimiento para obtener, a partir de la biopsia de un paciente, nuevos parámetros que permiten diagnosticar de manera objetiva ...