Raman Investigation Of Nanostructured Titania For Drug Delivery

Abstract

Controlled drug delivery systems are investigated to increase the chemical stability of the drug and to eliminate the side effects caused by the systemic administration via the circulatory system. Functionalized silica and titania xerogels are emerging as a new category of drug host systems. In the treatment of neurological disorders, which occur primarily in the central nervous system, a ceramic device can be implanted directly near a damaged tissue, thus avoiding passage through the blood brain barrier and reducing the necessary drug doses. Valproic acid (VPA), an often used anticonvulsant drug, encapsulated within a titania device has been successfully tested on mice as a therapy for epileptic disorders and is necessary to understand how to control the kinetics of drug release by changing the synthesis parameters.