dc.creator | Alfaro Juárez, Asunción | es |
dc.creator | Caro Magdaleno, Manuel | es |
dc.creator | Montero Iruzubieta, Jesús | es |
dc.creator | Fernández Palacín, Ana | es |
dc.creator | Muñoz Morales, Ana | es |
dc.creator | Castilla Martino, Manuel Alberto | es |
dc.creator | Rodríguez de la Rúa Franch, Enrique | es |
dc.date.accessioned | 2020-04-28T12:52:00Z | |
dc.date.available | 2020-04-28T12:52:00Z | |
dc.date.issued | 2019-10-16 | |
dc.identifier.citation | Alfaro Juárez, A., Caro Magdaleno, M., Montero Iruzubieta, J., Fernández Palacín, A., Muñoz Morales, A., Castilla Martino, M.A. y Rodríguez de la Rúa Franch, E. (2019). Keratograph 5M As A Useful And Objective Tool For Evaluating The Ocular Surface In Limbal Stem Cell Deficiency.. Clinical Opthalmology, 13, 2025-2033. | |
dc.identifier.issn | 1177-5483 | es |
dc.identifier.uri | https://hdl.handle.net/11441/95896 | |
dc.description.abstract | Purpose: In limbal stem cell deficiency, both the Ocular Surface Disease Index (OSDI)
questionnaire and tear break-up time (BUT) are comparable between traditional methods and
the Keratograph 5M. In this study, we aimed to correlate OSDI with Keratograph 5M
interviewed OSDI, as well as slit-lamp tear BUT with Keratograph 5M noninvasive tear
break-up time (NIKBUT) in limbal stem cell deficiency.
Patients and methods: Thirty-eight limbal stem cell-deficiency patients (76 eyes) from
Virgen Macarena-Rocio Hospital (Seville, Spain) underwent this diagnostic test study. All
patients completed the traditional OSDI. We measured the BUT, performed a Keratograph
5M analysis of NIKBUT first (employed for the analysis) followed by the average NIKBUT,
the level of dryness, and conducted the OSDI questionnaire through an interview. For each
pair of tests, we analyzed the means and applied an intraclass correlation coefficient (r),
creating a Bland-Altman plot for data dispersion.
Results: Average values were 47.5 points (±25.8), and 47.3 points (±27.5) for traditional
OSDI and Keratograph OSDI, respectively (P =0.87); the r value indicates good agreement
(0.72). The Bland-Altman plot followed a linear pattern, and the results were similarly
distributed. The NIKBUT mean was shorter than the BUT mean (P = 0.007); the r value
indicates moderate agreement (0.574). The Bland-Altman plot formed an almost horizontal
line, with almost all values between the mean and two standard deviations.
Conclusion: Keratograph 5M is useful for the evaluation of the ocular surface in limbal
stem cell deficiency. NIKBUT can substitute BUT based on its advantages of being non-
invasive, objective, with intraobserver and interobserver repeatability and reliability. The
Keratograph 5M OSDI is comparable to the traditional questionnaire. | es |
dc.description.sponsorship | Unión Europea RD16/0008/0010 | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Clinical Opthalmology, 13, 2025-2033. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Keratograph | es |
dc.subject | Limbal stem cell deficiency | es |
dc.subject | Noninvasive keratograph tear break-up time | es |
dc.subject | Ocular surface desease index | es |
dc.subject | Tear break-up time. | es |
dc.title | Keratograph 5M As A Useful And Objective Tool For Evaluating The Ocular Surface In Limbal Stem Cell Deficiency. | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública | es |
dc.identifier.doi | 10.2147/OPTH.S218313 | es |
dc.contributor.group | Universidad de Sevilla. CTS312: Análisis de la demanda sanitaria. | es |
dc.journaltitle | Clinical Opthalmology | es |
dc.publication.volumen | 13 | es |
dc.publication.initialPage | 2025 | es |
dc.publication.endPage | 2033 | es |