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dc.creatorCouso Liáñez, Inmaculada Concepciónes
dc.creatorPérez Pérez, Maria Estheres
dc.creatorFord, Megan M.es
dc.creatorMartínez Force, Enriquees
dc.creatorHicks, Leslie M.es
dc.creatorUmen, James G.es
dc.creatorCrespo González, José Luises
dc.date.accessioned2020-04-07T23:01:07Z
dc.date.available2020-04-07T23:01:07Z
dc.date.issued2020
dc.identifier.citationCouso Liáñez, I.C., Pérez Pérez, M.E., Ford, M.M., Martínez Force, E., Hicks, L.M., Umen, J.G. y Crespo González, J.L. (2020). Phosphorus Availability Regulates TORC1 Signaling via LST8 in Chlamydomonas. Plant Cell, 32 (1), 69-80.
dc.identifier.issn1532-298Xes
dc.identifier.urihttps://hdl.handle.net/11441/94979
dc.description.abstractTarget of rapamycin complex 1 (TORC1) is a central regulator of cell growth. It balances anabolic and catabolic processes in response to nutrients, growth factors, and energy availability. Nitrogen- and carbon-containing metabolites have been shown to activate TORC1 in yeast, animals, and plants. Here, we show that phosphorus (P) regulates TORC1 signaling in the model green alga Chlamydomonas (Chlamydomonas reinhardtii) via LST8, a conserved TORC1 subunit that interacts with the kinase domain of TOR. P starvation results in a sharp decrease in LST8 abundance and downregulation of TORC1 activity. A hypomorphic lst8 mutation resulted in decreased LST8 abundance, and it both reduced TORC1 signaling and altered the cellular response to P starvation. Additionally, we found that LST8 levels and TORC1 activity were not properly regulated in a mutant defective in the transcription factor PSR1, which is the major mediator of P deprivation responses in Chlamydomonas. Unlike wild-type cells, the psr1 mutant failed to downregulate LST8 abundance and TORC1 activity when under P limitation. These results identify PSR1 as an upstream regulator of TORC1 and demonstrate that TORC1 is a key component in P signaling in Chlamydomonas.es
dc.description.sponsorshipEspaña Ministerio de Economía y Competitividad (grants BFU2015-68216-P and PGC2018-099048- B-100 to J.L.C. and grant BIO2015-74432-JIN to M.E.P.-P.)es
dc.description.sponsorshipNational Science Foundation (CAREER award MCB-1552522 to L.M.H. and grant MCB-1616820 to J.G.U.)es
dc.description.sponsorshipEuropean Commission (grant number 750996)es
dc.formatapplication/pdfes
dc.format.extent11 p.es
dc.language.isoenges
dc.publisherAmerican Society of Plant Biologistses
dc.relation.ispartofPlant Cell, 32 (1), 69-80.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titlePhosphorus Availability Regulates TORC1 Signaling via LST8 in Chlamydomonases
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Moleculares
dc.relation.projectIDgrants BFU2015-68216-P and PGC2018-099048- B-100 to J.L.C. and grant BIO2015-74432-JIN to M.E.P.-P.es
dc.relation.projectIDCAREER award MCB-1552522 to L.M.H. and grant MCB-1616820 to J.G.U.es
dc.relation.projectIDgrant number 750996es
dc.relation.publisherversionhttp://dx.doi.org/10.1105/tpc.19.00179es
dc.identifier.doi10.1105/tpc.19.00179es
dc.journaltitlePlant Celles
dc.publication.volumen32es
dc.publication.issue1es
dc.publication.initialPage69es
dc.publication.endPage80es
dc.contributor.funderMinisterio de Economía y Competitividad (MINECO). Españaes
dc.contributor.funderNational Science Foundation (NSF). United Stateses
dc.contributor.funderEuropean Commission (EC)es

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