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dc.creatorFrattaruolo, L.es
dc.creatorCarullo, Ges
dc.creatorBrindisi, Mes
dc.creatorMazzotta, Sarahes
dc.creatorBellissimo, Les
dc.creatorRago, Ves
dc.creatorCurcio, Res
dc.date.accessioned2019-07-05T09:59:55Z
dc.date.available2019-07-05T09:59:55Z
dc.date.issued2019
dc.identifier.citationFrattaruolo, L., Carullo, G., Brindisi, M., Mazzotta, S., Bellissimo, L., Rago, V. y Curcio, R. (2019). Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway. Antioxidants, 8 (6), 1-15.
dc.identifier.issn2076-3921es
dc.identifier.urihttps://hdl.handle.net/11441/87884
dc.description.abstractInflammation represents an adaptive response generated by injuries or harmful stimuli. Natural remedies represent an interesting alternative to traditional therapies, involving several biochemical pathways. Besides, the valorization of agrochemical wastes nowadays seems to be a feasible way to reduce the health spending and improve the accessibility at bioactive natural compounds. In this context, the chemical composition of three Glycyrrhiza glabra L. (licorice) leaf extracts, obtained through maceration or ultrasound-assisted method (fresh and dried leaves) was investigated. A guided fractionation obtained three main components: pinocembrin, glabranin and licoflavanone. All the extracts showed similar antioxidant properties, evaluated by 2,2'-diphenyl-1-picrylhydrazyl (DPPH) or 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) Diammonium Salt (ABTS) assay, while, among the isolated compounds, licoflavanone exhibited the best antioxidant activity. The anti-inflammatory activity of the extracts and the purified compounds was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. Extract C and licoflavanone showed a good anti-inflammatory activity without affecting cell viability, as they decreased nitrite levels even when used at 12.5 μg/mL (p < 0.005) and 50 μM concentration (p < 0.001), respectively. Interestingly, licoflavanone markedly decreased pro-inflammatory cytokines and cyclooxygenase 2/inducible nitric oxide synthase (COX-2/iNOS) expression levels (p < 0.001). A modulation of nuclear factor kappa B/mitogen-activated protein kinases (NF-kB/MAPK) pathway underlay such behavior, highlighting the potential of this natural compound as a new scaffold in anti-inflammatory drug research.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofAntioxidants, 8 (6), 1-15.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGlycyrrhiza glabraes
dc.subjectNF-kB/MAPK pathwayes
dc.subjectanti-inflammatory activityes
dc.subjectantioxidant activityes
dc.subjectlicoflavanonees
dc.subjectpinocembrines
dc.titleAntioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathwayes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttp://dx.doi.org/10.3390/antiox8060186es
dc.identifier.doi10.3390/antiox8060186es
idus.format.extent15 p.es
dc.journaltitleAntioxidantses
dc.publication.volumen8es
dc.publication.issue6es
dc.publication.initialPage1es
dc.publication.endPage15es

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