dc.creator | Cordero, Mario D. | es |
dc.creator | Díaz-Parrado, Eduardo | es |
dc.creator | Carrión, Ángel Manuel | es |
dc.creator | Alfonsi, Simona | es |
dc.creator | Sánchez Alcázar, José Antonio | es |
dc.creator | Miguel Rodríguez, Manuel de | |
dc.creator | Battino, Maurizio | |
dc.creator | Miguel Rodríguez, Manuel de | |
dc.date.accessioned | 2019-01-24T17:54:03Z | |
dc.date.available | 2019-01-24T17:54:03Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Bullon, P., Cordero, M.D., Díaz-Parrado, E., Carrión, Á.M., Alfonsi, S. y Sánchez Alcázar, J.A. (2013). Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?. Antioxidants and redox signaling, 18 (7), 800-807. | |
dc.identifier.issn | 1557-7716 | es |
dc.identifier.uri | https://hdl.handle.net/11441/82046 | |
dc.description.abstract | Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the possible relationship between mitochondrial dysfunction, oxidative stress, and inflammation in FM. We studied 30 women diagnosed with FM and 20 healthy women. Blood mononuclear cells (BMCs) from FM patients showed reduced level of coenzyme Q10 (CoQ10) and mtDNA contents and high level of mitochondrial reactive oxygen species (ROS) and serum tumor necrosis factor (TNF)-alpha and transcript levels. A significant negative correlation between CoQ10 and TNF-alpha levels (r= -0.588; p < 0.01), and a positive correlation between ROS and TNF-alpha levels (r = 0.791; p < 0.001) were observed accompanied by a significant correlation of visual analogical scale with serum TNF-alpha and transcript levels (r = 0.4507; p < 0.05 and r = 0.7089; p < 0.001, respectively). TNF-alpha release was observed in an in vitro (BMCs) and in vivo (mice) CoQ10 deficiency model. Oral CoQ10 supplementation restored biochemical parameters and induced a significant
improvement in clinical symptoms ( p < 0.001). These results lead to the hypothesis that inflammation could be a mitochondrial dysfunction-dependent event implicated in the pathophysiology of FM in several patients indicating
at mitochondria as a possible new therapeutic target. | es |
dc.description.sponsorship | Unión Europea FIS PI10/00543 | es |
dc.description.sponsorship | Servicio Andaluz de Salud Junta de Andalucía SAS 111242 | es |
dc.description.sponsorship | Junta de Andalucía CTS-5725 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Mary Ann Liebert, Inc. | es |
dc.relation.ispartof | Antioxidants and redox signaling, 18 (7), 800-807. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Fibromyalgia | es |
dc.subject | mitochondrial dysfunction | es |
dc.subject | inflammation | es |
dc.subject | FM | es |
dc.title | Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia? | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estomatología | es |
dc.relation.projectID | CTS113 | es |
dc.identifier.doi | 10.1089/ars.2012.4892 | es |
dc.contributor.group | Universidad de Sevilla. CTS 113: Investigacion Etiologia y Patogenia Periodontal, Patologia Oral y Enfermedades Musculares | es |
idus.format.extent | 8 | es |
dc.journaltitle | Antioxidants and redox signaling | es |
dc.publication.volumen | 18 | es |
dc.publication.issue | 7 | es |
dc.publication.initialPage | 800 | es |
dc.publication.endPage | 807 | es |