dc.creator | Recio Jiménez, Rocío | es |
dc.creator | Elhalem, Eleonora | es |
dc.creator | Benito, Juan M. | es |
dc.creator | Fernández Fernández, Inmaculada | es |
dc.creator | Khiar, Noureddine | es |
dc.date.accessioned | 2019-01-10T12:55:48Z | |
dc.date.available | 2019-01-10T12:55:48Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Recio Jiménez, R., Elhalem, E., Benito, J.M., Fernández Fernández, I. y Khiar, N. (2018). NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins. Carbohydrate Polymers, 187, 118-125. | |
dc.identifier.issn | 0144-8617 | es |
dc.identifier.uri | https://hdl.handle.net/11441/81435 | |
dc.description.abstract | Sulforaphane (SFN), a phytochemical isolated from broccoli, is an important antitumoral compound with additional beneficial effect on other important diseases. However, the chemical instability of SFN has hampered its
clinical use. In order to circumvent this problem, we report the first comparative study on the inclusion complexes of SFN and SFN homologues with different cyclodextrins by NMR spectroscopy. From this study it has
been shown that α-CD is the most indicated cyclodextrin for the stabilization of SFN and SFN homologues, and
that the highest affinity constant is that of the isothiocyanate obtained from the wasabi. Furthermore, the study
of the inclusion complexes of α-CD and the non-natural SFN and analogues with S absolute configuration at
sulfur shows for the first time that α-CD is able to discriminate between the two enantiomers, with the natural R
enantiomers forming the inclusion complexes with higher affinity. | es |
dc.description.sponsorship | Ministerio de Economía yCompetitividad (grants No. CTQ2016-78580-C2-1-R, and CTQ2016-78580-C2-2-R) | es |
dc.description.sponsorship | Junta de Andalucía (P11-FQM-8046) | es |
dc.description.sponsorship | EvgenPharma | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Carbohydrate Polymers, 187, 118-125. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Sulforaphane | es |
dc.subject | Sulforaphane analogues | es |
dc.subject | Sulforaphane stabilty | es |
dc.subject | Cyclodextrins | es |
dc.subject | Chiral discrimination | es |
dc.subject | Affinity constants | es |
dc.title | NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.relation.projectID | P11-FQM-8046 | es |
dc.relation.projectID | CTQ2016-78580-C2-1-R | es |
dc.relation.projectID | CTQ2016-78580-C2-2-R | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.carbpol.2017.12.022 | es |
dc.identifier.doi | 10.1016/j.carbpol.2017.12.022 | es |
idus.format.extent | 8 p. | es |
dc.journaltitle | Carbohydrate Polymers | es |
dc.publication.volumen | 187 | es |
dc.publication.initialPage | 118 | es |
dc.publication.endPage | 125 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | |
dc.contributor.funder | Junta de Andalucía | |
dc.description.awardwinning | Premio Mensual Publicación Científica Destacada de la US. Facultad de Farmacia | |