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Artículo
Megahertz serial crystallography
dc.creator | Wiedorn, Max O. | es |
dc.creator | Oberthür, Dominik | es |
dc.creator | Bean, Richard | es |
dc.creator | Cruz-Mazo, Francisco | es |
dc.creator | Gañán-Calvo, Alfonso M. | es |
dc.date.accessioned | 2018-11-12T08:48:36Z | |
dc.date.available | 2018-11-12T08:48:36Z | |
dc.date.issued | 2018-10 | |
dc.identifier.citation | Wiedorn, M.O.(et al.) (2018). Megahertz serial crystallography. Nature Communications, 9 (1), Article number 4025-. | |
dc.identifier.issn | 2041-1723 | es |
dc.identifier.uri | https://hdl.handle.net/11441/80031 | |
dc.description.abstract | The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Nature Publishing | es |
dc.relation.ispartof | Nature Communications, 9 (1), Article number 4025-. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Megahertz serial crystallography | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ingeniería Aeroespacial y Mecánica de Fluidos | es |
dc.relation.publisherversion | https://www.nature.com/articles/s41467-018-06156-7 | es |
dc.identifier.doi | 10.1038/s41467-018-06156-7 | es |
idus.format.extent | 11 | es |
idus.validador.nota | Acceso Abierto (CC BY) | es |
dc.journaltitle | Nature Communications | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | Article number 4025 | es |
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