Show simple item record

dc.creatorGonzalo Calvo, Gonzalo dees
dc.date.accessioned2018-08-06T08:20:24Z
dc.date.available2018-08-06T08:20:24Z
dc.date.issued2018
dc.identifier.citationGonzalo Calvo, G.d. (2018). Lipase catalysed kinetic resolution of racemic 1,2-diols containing a chiral quaternary center. Molecules, 23, 1585-1-1585-10.
dc.identifier.issn1420-3049es
dc.identifier.urihttps://hdl.handle.net/11441/77844
dc.description.abstractOptically active 1,2-diols are valuable buildings blocks in organic synthesis. In the present paper, a set of racemic 1,2-diols with an ester functional group are prepared, starting from -ketoesters in a three-step procedure with moderate yields. The racemic 1,2-diols, containing a chiral quaternary center in their structure, are subjected to selective acylation in order to perform their kinetic resolution catalysed by a set of commercially available lipases. Under optimized reaction conditions, good conversions and enantioselectivities are achieved by using the lipase PSL-C from Pseudomonas cepacia in tert-butyl methyl ether. This biocatalyst could be reused up to five times without losing its properties.es
dc.description.sponsorshipMinisterio de Economía y Competitividad (contract RYC-2012-10014 for G.d.G., Grants CTQ2016-76908-C2-1-P and CTQ2016-76908-C2-2-P)es
dc.description.sponsorshipEuropean FEDER Fundses
dc.description.sponsorshipJunta de Andalucía (Grant 2012/FQM 10787)es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofMolecules, 23, 1585-1-1585-10.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiocatalysises
dc.subjectLipaseses
dc.subjectKinetic resolutiones
dc.subject1,2-diolses
dc.titleLipase catalysed kinetic resolution of racemic 1,2-diols containing a chiral quaternary centeres
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química Orgánicaes
dc.relation.projectIDRYC-2012-10014es
dc.relation.projectIDCTQ2016-76908-C2-1-Pes
dc.relation.projectIDCTQ2016-76908-C2-2-Pes
dc.relation.projectID2012/FQM 10787es
dc.relation.publisherversionhttp://www.mdpi.com/1420-3049/23/7/1585es
dc.identifier.doi10.3390/molecules23071585es
idus.format.extent10 p.es
dc.journaltitleMoleculeses
dc.publication.volumen23es
dc.publication.initialPage1585-1es
dc.publication.endPage1585-10es

FilesSizeFormatViewDescription
molecules-23-01585.pdf1.322MbIcon   [PDF] View/Open  

This item appears in the following collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional