Artículo
Lipase catalysed kinetic resolution of racemic 1,2-diols containing a chiral quaternary center
Autor/es | Gonzalo Calvo, Gonzalo de |
Departamento | Universidad de Sevilla. Departamento de Química Orgánica |
Fecha de publicación | 2018 |
Fecha de depósito | 2018-08-06 |
Publicado en |
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Resumen | Optically active 1,2-diols are valuable buildings blocks in organic synthesis. In the present
paper, a set of racemic 1,2-diols with an ester functional group are prepared, starting from -ketoesters
in a three-step ... Optically active 1,2-diols are valuable buildings blocks in organic synthesis. In the present paper, a set of racemic 1,2-diols with an ester functional group are prepared, starting from -ketoesters in a three-step procedure with moderate yields. The racemic 1,2-diols, containing a chiral quaternary center in their structure, are subjected to selective acylation in order to perform their kinetic resolution catalysed by a set of commercially available lipases. Under optimized reaction conditions, good conversions and enantioselectivities are achieved by using the lipase PSL-C from Pseudomonas cepacia in tert-butyl methyl ether. This biocatalyst could be reused up to five times without losing its properties. |
Identificador del proyecto | RYC-2012-10014
CTQ2016-76908-C2-1-P CTQ2016-76908-C2-2-P 2012/FQM 10787 |
Cita | Gonzalo Calvo, G.d. (2018). Lipase catalysed kinetic resolution of racemic 1,2-diols containing a chiral quaternary center. Molecules, 23, 1585-1-1585-10. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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molecules-23-01585.pdf | 1.322Mb | [PDF] | Ver/ | |