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Artículo
Synthesis of IAN-type N,N-Ligands via Dynamic Kinetic Asymmetric Buchwald-Hartwig Amination
Autor/es | Ramírez-López, Pedro
Ros, Abel Romero Arenas, Antonio Iglesias Sigüenza, Francisco Javier Fernández Fernández, Rosario Fátima Lassaletta, José M. |
Departamento | Universidad de Sevilla. Departamento de Química Orgánica |
Fecha de publicación | 2016 |
Fecha de depósito | 2018-06-20 |
Publicado en |
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Resumen | The Pd-catalyzed coupling of racemic heterobiaryl bromides, triflates, or nonaflates with aryl/alkyl primary amines using QUINAP as the ligand provides the corresponding axially chiral heterobiaryl amines with excellent ... The Pd-catalyzed coupling of racemic heterobiaryl bromides, triflates, or nonaflates with aryl/alkyl primary amines using QUINAP as the ligand provides the corresponding axially chiral heterobiaryl amines with excellent yields and enantioselectivities. Reactivity and structural studies of neutral and cationic oxidative addition intermediates support a dynamic kinetic asymmetric amination mechanism based on the labilization of the stereogenic axis in the latter and suggest that coordination of the amine to the Pd center is the stereodetermining step. |
Cita | Ramírez-López, P., Ros, A., Romero-Arenas, A., Iglesias Sigüenza, F.J., Fernández, R. y Lassaletta, J.M. (2016). Synthesis of IAN-type N,N-Ligands via Dynamic Kinetic Asymmetric Buchwald-Hartwig Amination. Journal of the American Chemical Society, 138 (37), 12053-12056. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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synthesis of IAN-type.pdf | 608.0Kb | [PDF] | Ver/ | |