dc.creator | Pflueger, Iris | es |
dc.creator | Charrat, Coralie | es |
dc.creator | Ortiz Mellet, Carmen | es |
dc.creator | García Fernández, José Manuel | es |
dc.creator | Di Giorgio, Christophe | es |
dc.creator | Benito, Juan M. | es |
dc.date.accessioned | 2018-06-07T14:52:02Z | |
dc.date.available | 2018-06-07T14:52:02Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Pflueger, I., Charrat, C., Ortiz Mellet, C., García Fernández, J.M., Di Giorgio, C. y Benito, J.M. (2016). Cyclodextrin-based facial amphiphiles: Assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities. Organic and Biomolecular Chemistry, 14, 10037-10049. | |
dc.identifier.issn | 1477-0520 (impreso) | es |
dc.identifier.issn | 1477-0539 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/75855 | |
dc.description.abstract | Exhaustive structure–efficacy relationship studies on nonviral gene delivery systems are often hampered by the ill-defined or polydisperse nature of the formulations. Facial amphiphiles based on rigid cage-type molecular scaffolds offer unique possibilities towards these studies. Taking advantage of regioselective functionalization schemes, we have synthesized a library of cationic cyclodextrin (CD) derivatives combining a range of hydrophilic and lipophilic domains. We have scrutinized how the hydrophilic–lipophilic balance (HLB) around the CD scaffold determines their self-assembly capabilities and the DNA binding and release abilities of the corresponding CD[thin space (1/6-em)]:[thin space (1/6-em)]DNA nanocomplexes (CDplexes). These features have been ultimately correlated with their capabilities to deliver a reporter luciferase-encoding pDNA into COS-7 cells. The ensemble of results demonstrates that fine tuning of the HLB is critical to induce compaction of DNA by the CD-based facial amphiphiles into transfection-productive CDplexes. | es |
dc.description.sponsorship | Ministerio de Economia y Competitividad SAF2013- 44021-R | es |
dc.description.sponsorship | Junta de Andalucía FQM2012- 1467 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Royal Society of Chemistry | es |
dc.relation.ispartof | Organic and Biomolecular Chemistry, 14, 10037-10049. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Cyclodextrin-based facial amphiphiles: Assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.relation.publisherversion | http://dx.doi.org/10.1039/c6ob01882c | es |
dc.identifier.doi | 10.1039/c6ob01882c | es |
idus.format.extent | 15 p. | es |
dc.journaltitle | Organic and Biomolecular Chemistry | es |
dc.publication.issue | 14 | es |
dc.publication.initialPage | 10037 | es |
dc.publication.endPage | 10049 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | |
dc.contributor.funder | Junta de Andalucía | |