Mostrar el registro sencillo del ítem
Artículo
Dimerization model of the C-terminal RNA Recognition Motif of HuR
dc.creator | Díaz Quintana, Antonio Jesús | es |
dc.creator | García Mauriño, Sofía M. | es |
dc.creator | Díaz Moreno, Irene | es |
dc.date.accessioned | 2018-01-18T12:34:21Z | |
dc.date.available | 2018-01-18T12:34:21Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Díaz Quintana, A., García Mauriño, S.M. y Díaz Moreno, I. (2015). Dimerization model of the C-terminal RNA Recognition Motif of HuR. FEBS Letters, 589 (10), 1059-1066. | |
dc.identifier.issn | 0014-5793 | es |
dc.identifier.uri | https://hdl.handle.net/11441/69174 | |
dc.description.abstract | Human antigen R (HuR) is a ubiquitous 32kDa protein comprising three RNA Recognition Motifs (RRMs), whose main function is to bind Adenylate and uridylate Rich Elements (AREs) in 3′ UnTranslated Regions (UTRs) of mRNAs. In addition to binding RNA molecules, the third domain (RRM3) is involved in HuR oligomerization and apoptotic signaling. The RRM3 monomer is able to dimerize, with its self-binding affinity being dependent on ionic strength. Here we provide a deeper structural insight into the nature of the encounter complexes leading to the formation of RRM3 dimers by using Brownian Dynamics and Molecular Dynamics. Our computational data show that the initial unspecific encounter follows a downhill pathway until reaching an optimum conformation stabilized by hydrophobic interactions. | es |
dc.description.sponsorship | Junta de Andalucía P07-CVI-02896, P11-CVI-07216 and 290 BIO198 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | wiley | es |
dc.relation.ispartof | FEBS Letters, 589 (10), 1059-1066. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Dimerization | es |
dc.subject | Human antigen R (HuR) | es |
dc.subject | RNA Binding Protein | es |
dc.subject | RNA Recognition Motif (RRM) | es |
dc.subject | Brownian Dynamics (BD) | es |
dc.subject | Molecular Dynamics (MD) | es |
dc.title | Dimerization model of the C-terminal RNA Recognition Motif of HuR | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/submittedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | es |
dc.relation.projectID | P07-CVI-02896 | es |
dc.relation.projectID | P11-CVI-07216 | es |
dc.relation.projectID | 290 BIO198 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.febslet.2015.03.013 | es |
dc.identifier.doi | 10.1016/j.febslet.2015.03.013 | es |
idus.format.extent | 7 p. | es |
dc.journaltitle | FEBS Letters | es |
dc.publication.volumen | 589 | es |
dc.publication.issue | 10 | es |
dc.publication.initialPage | 1059 | es |
dc.publication.endPage | 1066 | es |
dc.contributor.funder | Junta de Andalucía |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
csic10dimerization_model_Diaz.pdf | 2.262Mb | ![]() | Ver/ | |