Fabrication of Gelatin/Bioactive Glass Hybrid Scaffolds for Bone Tissue- Engineering

Abstract

In this work, hybrid scaffold materials composed of gelatin and Bioactive Glass (BG) have been fabricated. BG particulates in the ternary system SiO2 − CaO − P 2 O 5 have been synthesized initially using the sol-gel method. The gelatin/BG scaffolds were shaped by a freeze-drying process obtaining homogeneous and reproducible final macroporous structures. BG particulates precursor and the final hybrid macroporous structures (scaffolds) were characterized using Field Emission Scanning Electron Microscopy (FE-SEM), Energy Dispersive X-ray Analysis (EDX), X-ray diffraction (XRD) and thermal analysis. Finally, the scaffolds were essayed in Simulated Body Fluid (SBF) in vitro showing a bioactive response.