Cysteine and cysteine-related signaling pathways in arabidopsis thaliana
|Author/s||Romero González, Luis Carlos
Aroca Aguilar, Ángeles
Laureano Marín, Ana María
Moreno González, María Inmaculada
García Fernández, Irene
Gotor Martínez, Cecilia
|Department||Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular|
|Abstract||Cysteine occupies a central position in plant metabolism because it is a reduced sulfur donor molecule involved in the synthesis of essential biomolecules and defense compounds. Moreover, cysteine per se and its derivative ...
Cysteine occupies a central position in plant metabolism because it is a reduced sulfur donor molecule involved in the synthesis of essential biomolecules and defense compounds. Moreover, cysteine per se and its derivative molecules play roles in the redox signaling of processes occurring in various cellular compartments. Cysteine is synthesized during the sulfate assimilation pathway via the incorporation of sulfide to O-acetylserine, catalyzed by O-acetylserine(thiol)lyase (OASTL). Plant cells contain OASTLs in the mitochondria, chloroplasts, and cytosol, resulting in a complex array of isoforms and subcellular cysteine pools. In recent years, significant progress has been made in Arabidopsis, in determining the specific roles of the OASTLs and the metabolites produced by them. Thus, the discovery of novel enzymatic activities of the less-abundant, like DES1 with L-cysteine desulfhydrase activity and SCS with S-sulfocysteine synthase activity, has provided new perspectives on their roles, besides their metabolic functions. Thereby, the research has been demonstrated that cytosolic sulfide and chloroplastic S-sulfocysteine act as signaling molecules regulating autophagy and protecting the photosystems, respectively. In the cytosol, cysteine plays an essential role in plant immunity; in the mitochondria, this molecule plays a central role in the detoxification of cyanide, which is essential for root hair development and plant responses to pathogens.
|Funding agencies||Ministerio de Economía y Competitividad (MINECO). España
Junta de Andalucía
|Citation||Romero González, L.C., Aroca Aguilar, M.Á., Laureano Marín, A.M., Moreno González, M.I., García Fernández, I. y Gotor Martínez, C. (2014). Cysteine and cysteine-related signaling pathways in arabidopsis thaliana. Molecular Plant, 7, 264-276.|