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dc.creatorLópez Cortés, Luis Fernandoes
dc.creatorRuiz Valderas, Rosaes
dc.creatorLucero Muñoz, María Jesúses
dc.creatorCordero Matia, María Elisaes
dc.creatorPastor Ramos, M. T.es
dc.creatorMárquez, Javieres
dc.date.accessioned2017-09-28T17:15:37Z
dc.date.available2017-09-28T17:15:37Z
dc.date.issued2000-03-01
dc.identifier.citationLópez Cortés, L.F., Ruiz Valderas, R., Lucero Muñoz, M.J., Cordero, E., Pastor Ramos, M.T. y Márquez, J. (2000). Intravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbits. Antimicrobial Agents and Chemotherapy, 44 (3), 756-759.
dc.identifier.issn0066-4804 (impreso)es
dc.identifier.issn1098-6596 (electrónico)es
dc.identifier.urihttp://hdl.handle.net/11441/64863
dc.description.abstractRetinal, vitreous humor, brain, and cerebrospinal fluid (CSF) foscarnet levels were measured by high-performance liquid chromatography after administration of an intravenous dose of 120 mg/kg of body weight to 32 pigmented rabbits. A pharmacokinetic analysis was done using a two- compartment model. The penetration ratios, defined as ratios of retinal, vitreous humor, brain, and CSF areas under the concentration-time curve from 0 to 2 h were 110% ± 1%, 12.3% ± 0.7%, 118% ± 1%, and 20.2% ± 2.2%, respectively. These results suggest a good penetration of foscarnet into the retinal and brain tissues, reaching higher concentrations than those estimated from vitreous humor and CSF levels.es
dc.description.sponsorshipComisóión Interministerial de Ciencia y Tecnología SAF97-0012es
dc.description.sponsorshipConsejería de Salud Junta de Andalucía 64/96es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Society for Microbiologyes
dc.relation.ispartofAntimicrobial Agents and Chemotherapy, 44 (3), 756-759.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleIntravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbitses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéuticaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.projectIDSAF97-0012es
dc.relation.projectID64/96es
dc.relation.publisherversionhttp://dx.doi.org/10.1128/AAC.44.3.756-759.2000es
dc.identifier.doi10.1128/AAC.44.3.756-759.2000es
idus.format.extent4 p.es
dc.journaltitleAntimicrobial Agents and Chemotherapyes
dc.publication.volumen44es
dc.publication.issue3es
dc.publication.initialPage756es
dc.publication.endPage759es
dc.contributor.funderComisión Interministerial de Ciencia y Tecnología (CICYT). España
dc.contributor.funderJunta de Andalucía

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