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dc.creatorMarín-Aguilar, Fabiolaes
dc.creatorPavillard, Luis E.es
dc.creatorGiampieri, Francescaes
dc.creatorBullon, Pedroes
dc.creatorCordero, Mario D.es
dc.date.accessioned2017-09-27T07:05:53Z
dc.date.available2017-09-27T07:05:53Z
dc.date.issued2017
dc.identifier.citationMarín-Aguilar, F., Pavillard, L.E., Giampieri, F., Bullon, P. y Cordero, M.D. (2017). Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds. International journal of molecular sciences, 18 (2), 1-24.
dc.identifier.issn1422-0067es
dc.identifier.urihttp://hdl.handle.net/11441/64746
dc.description.abstractAdenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and/or adenosine diphosphate (ADP)/ATP ratio, and increases different metabolic pathways such as fatty acid oxidation, glucose transport and mitochondrial biogenesis. In this sense, AMPK maintains cellular energy homeostasis by induction of catabolism and inhibition of ATP-consuming biosynthetic pathways to preserve ATP levels. Several studies indicate a reduction of AMPK sensitivity to cellular stress during aging and this could impair the downstream signaling and the maintenance of the cellular energy balance and the stress resistance. However, several diseases have been related with an AMPK dysfunction. Alterations in AMPK signaling decrease mitochondrial biogenesis, increase cellular stress and induce inflammation, which are typical events of the aging process and have been associated to several pathological processes. In this sense, in the last few years AMPK has been identified as a very interesting target and different nutraceutical compounds are being studied for an interesting potential effect on AMPK induction. In this review, we will evaluate the interaction of the different nutraceutical compounds to induce the AMPK phosphorylation and the applications in diseases such as cancer, type II diabetes, neurodegenerative diseases or cardiovascular diseases.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMolecular Diversity Preservation International (MDPI)es
dc.relation.ispartofInternational journal of molecular sciences, 18 (2), 1-24.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAdenosine monophosphate-activated protein kinase (AMPK)es
dc.subjectNutraceutical compoundses
dc.subjectCanceres
dc.subjectType II diabeteses
dc.subjectNeurodegenerative diseaseses
dc.subjectCardiovascular diseaseses
dc.titleAdenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compoundses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Estomatologíaes
dc.identifier.doi10.3390/ijms18020288es
idus.format.extent24es
dc.journaltitleInternational journal of molecular scienceses
dc.publication.volumen18es
dc.publication.issue2es
dc.publication.initialPage1es
dc.publication.endPage24es

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