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dc.creatorRomán Malo, Lourdes Victoriaes
dc.creatorBullon, Pedroes
dc.date.accessioned2017-09-26T11:53:50Z
dc.date.available2017-09-26T11:53:50Z
dc.date.issued2017-07
dc.identifier.citationRomán Malo, L.V. y Bullon, P. (2017). Influence of the Periodontal Disease, the Most Prevalent Inflammatory Event, in Peroxisome Proliferator-Activated Receptors Linking Nutrition and Energy Metabolism. International journal of molecular sciences, 18 (7), 1-13.
dc.identifier.issn1422-0067es
dc.identifier.urihttp://hdl.handle.net/11441/64723
dc.description.abstractPeriodontal disease is considered one of the main pathologic diseases occurring in humans. Its pathologic process involves inflammatory reactions producing periodontal bone resorption and the tooth loss. But some patients do not present an evident clinical inflammation with bone resorption, and in others, the inflammation is prominent without bone resorption. A key question could be to investigate a different way of responding to aggression. Inflammation requires a complex intracellular metabolic process, starting with the harmful recognition and activation of the inflammasome, continues the energy supply with the alteration of oxidative stress conditions, and finishes with the elimination of the aggression with autophagy/apoptosis mechanisms, then concludes with recovery. Peroxisome proliferator-activated receptors (PPARs) are essential molecules produced in inflammation, and its genes and its activation have been related to periodontal disease. Also, an important aspect is the influence of PPARs in bone metabolism; the main periodontitis symptom is bone loss and PPARγ activation that can downregulate the bone resorption in experimental periodontitis, PPARγ-coated titanium dental implant surfaces could carry the antiinflammatory gene and restrain inflammation. PPARs could be one of the meeting background points with atherosclerosis/cardiovascular disease, diabetes and metabolic syndrome showing a modified proinflammatory statement such as it is described in periodontitis.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMolecular Diversity Preservation International (MDPI)es
dc.relation.ispartofInternational journal of molecular sciences, 18 (7), 1-13.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPeriodontitises
dc.subjectInflammasomees
dc.subjectMitochondriaes
dc.subjectAutophagyes
dc.subjectAtherosclerosis diabeteses
dc.subjectMetabolic síndromees
dc.titleInfluence of the Periodontal Disease, the Most Prevalent Inflammatory Event, in Peroxisome Proliferator-Activated Receptors Linking Nutrition and Energy Metabolismes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Estomatologíaes
dc.identifier.doi10.3390/ijms18071438es
idus.format.extent13es
dc.journaltitleInternational journal of molecular scienceses
dc.publication.volumen18es
dc.publication.issue7es
dc.publication.initialPage1es
dc.publication.endPage13es

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