Artículo
Osteoconductive Potential of Barrier NanoSiO2 PLGA Membranes Functionalized by Plasma Enhanced Chemical Vapour Deposition
Autor/es | Terriza Fernández, Antonia
Vilches Pérez, José Ignacio Orden, Emilio de la Yubero Valencia, Francisco González Caballero, Juan Luis Rodríguez González-Elipe, Agustín Vilches, José Salido, Mercedes |
Fecha de publicación | 2014 |
Fecha de depósito | 2017-08-21 |
Publicado en |
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Resumen | The possibility of tailoring membrane surfaces with osteoconductive potential, in particular in biodegradable devices, to create modified biomaterials that stimulate osteoblast response should make them more suitable for ... The possibility of tailoring membrane surfaces with osteoconductive potential, in particular in biodegradable devices, to create modified biomaterials that stimulate osteoblast response should make them more suitable for clinical use, hopefully enhancing bone regeneration. Bioactive inorganic materials, such as silica, have been suggested to improve the bioactivity of synthetic biopolymers. An in vitro study on HOB human osteoblasts was performed to assess biocompatibility and bioactivity of SiO2 functionalized poly(lactide-co-glycolide) (PLGA) membranes, prior to clinical use. A 15 nm SiO2 layer was deposited by plasma enhanced chemical vapour deposition (PECVD), onto a resorbable PLGA membrane. Samples were characterized by X-ray photoelectron spectroscopy, atomic force microscopy, scanning electron microscopy, and infrared spectroscopy (FT-IR). HOB cells were seeded on sterilized test surfaces where cell morphology, spreading, actin cytoskeletal organization, and focal adhesion expression were assessed. As proved by the FT-IR analysis of samples, the deposition by PECVD of the SiO2 onto the PLGA membrane did not alter the composition and other characteristics of the organic membrane. A temporal and spatial reorganization of cytoskeleton and focal adhesions and morphological changes in response to SiO2 nanolayer were identified in our model. The novedous SiO2 deposition method is compatible with the standard sterilization protocols and reveals as a valuable tool to increase bioactivity of resorbable PLGA membranes. |
Identificador del proyecto | P09-CTS-5189
TEP5283 FQM-6900 CONSOLIDER CSD 2008-00023 MAT2010-21228 MAT2010-18447 FIS PI 09/00508 |
Cita | Terriza Fernández, A., Vilches Pérez, J.I., De la Orden, E., Yubero Valencia, F., González Caballero, J.L., Rodríguez González-Elipe, A.,...,Salido, M. (2014). Osteoconductive Potential of Barrier NanoSiO2 PLGA Membranes Functionalized by Plasma Enhanced Chemical Vapour Deposition. BioMed Research International, 253590, 1-10. |
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