Show simple item record

dc.creatorSánchez Barrionuevo, Leyrees
dc.creatorGonzález Benjumea, Alejandroes
dc.creatorEscobar Niño, Almudenaes
dc.creatorGarcía Gutiérrez, María Teresaes
dc.creatorLópez López, Óscares
dc.creatorMaya Castilla, Inéses
dc.creatorFernández-Bolaños Guzmán, José Maríaes
dc.creatorCánovas López, Davides
dc.creatorMellado Durán, María Encarnaciónes
dc.date.accessioned2017-02-03T11:11:23Z
dc.date.available2017-02-03T11:11:23Z
dc.date.issued2016
dc.identifier.citationSánchez Barrionuevo, L., González Benjumea, A., Escobar Niño, A., García Gutiérrez, M.T., López López, Ó., Maya Castilla, I.,...,Mellado Durán, M.E. (2016). A Straightforward Access to New Families of Lipophilic Polyphenols by Using Lipolytic Bacteria. PLoS One, 11 (11), e0166561-.
dc.identifier.issn1932-6203es
dc.identifier.urihttp://hdl.handle.net/11441/53610
dc.description.abstractThe chemical synthesis of new lipophilic polyphenols with improved properties presents technical difficulties. Here we describe the selection, isolation and identification of lipolytic bacteria from food-processing industrial wastes, and their use for tailoring a new set of com- pounds with great interest in the food industry. These bacteria were employed to produce lipolytic supernatants, which were applied without further purification as biocatalysts in the chemoselective and regioselective synthesis of lipophilic partially acetylated phenolic com- pounds derived from olive polyphenols. The chemoselectivity of polyphenols acylation/dea- cylation was analyzed, revealing the preference of the lipases for phenolic hydroxyl groups and phenolic esters. In addition, the alcoholysis of peracetylated 3,4-dihydroxyphenylglycol resulted in a series of lipophilic 2-alkoxy-2-(3,4-dihydroxyphenyl)ethyl acetate through an unexpected lipase-mediated etherification at the benzylic position. These new compounds are more lipophilic and retained their antioxidant properties. This approach can provide access to unprecedented derivatives of 3,4-dihydroxyphenylglycol with improved propertieses
dc.description.sponsorshipJunta de Andalucía P08-NMR-3515, P11-CVI-7427 MO, FQM134 y BIO-213es
dc.description.sponsorshipEuropean Regional Development Fund (FEDER)es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPLoS One, 11 (11)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleA Straightforward Access to New Families of Lipophilic Polyphenols by Using Lipolytic Bacteriaes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Microbiología y Parasitologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Genéticaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química orgánicaes
dc.relation.projectIDP08-NMR-3515es
dc.relation.projectIDP11-CVI-7427 MOes
dc.relation.projectIDFQM134es
dc.relation.projectIDBIO-213es
dc.relation.publisherversion10.1371/journal.pone.0166561es
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0166561es
idus.format.extent19 p.es
dc.journaltitlePLOS Onees
dc.publication.volumen11es
dc.publication.issue11es
dc.contributor.funderJunta de Andalucía
dc.contributor.funderEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)

FilesSizeFormatViewDescription
A Straightforward access.pdf1.551MbIcon   [PDF] View/Open  

This item appears in the following collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional