P systems-based Modelling of Cellular Signalling Pathways

Abstract

Cellular signalling pathways are fundamental to the control and regulation of cell behaviour. Understanding the biosignalling network functions are crucial for studying di erent diseases and for designing e ective therapeutic approaches to them. In this paper we present P systems as a feasible computational modelling tool for cellular signalling pathways that takes into consideration the inherent randomness occurring in biological phenomena and the discrete character of the components of the system. We illustrate these cellular models simulating the EGFR signalling cascade and the FAS{induced apoptosis using a deterministic strategy for evolution of P systems.