dc.creator | Mena, Auxiliadora | es |
dc.creator | Ruiz-Salas, Juan C. | es |
dc.creator | Puentes, Andrea | es |
dc.creator | Dorado, Inmaculada | es |
dc.creator | Ruiz Veguilla, Miguel | es |
dc.creator | Casa Rivas, Luis Gonzalo de La | es |
dc.date.accessioned | 2016-10-20T10:20:01Z | |
dc.date.available | 2016-10-20T10:20:01Z | |
dc.date.issued | 2016-10-18 | |
dc.identifier.citation | A. Mena, , J.C. Ruiz-Salas, , A. Puentes, , I. Dorado, , M. Ruiz-Veguilla, y L.G. De la Casa, (2016). Reduced Prepulse Inhibition as a Biomarker of Schizophrenia. Frontiers in Behavioral Neurosciences, 10 | |
dc.identifier.issn | 1662-5153 | es |
dc.identifier.uri | http://hdl.handle.net/11441/47846 | |
dc.description.abstract | The startle response is composed by a set of reflex behaviors intended to prepare the organism to face a potentially relevant stimulus. This response can be modulated by several factors as, for example, repeated presentations of the stimulus (startle habituation), or by previous presentation of a weak stimulus (Prepulse Inhibition [PPI]). Both phenomena appear disrupted in schizophrenia that is thought to reflect an alteration in dopaminergic and glutamatergic neurotransmission. In this paper we analyze whether the reported deficits are indicating a transient effect restricted to the acute phase of the disease, or if it reflects a more general biomarker or endophenotype of the disorder. To this end, we measured startle responses in the same set of thirteen schizophrenia patients with a cross-sectional design at two periods: 5 days after hospital admission and 3 months after discharge. The results showed that both startle habituation and PPI were impaired in the schizophrenia patients at the acute stage as compared to a control group composed by 13 healthy participants, and that PPI but not startle habituation remained disrupted when registered 3 months after the discharge. These data point to the consideration of PPI, but not startle habituation, as a schizophrenia biomarker. | es |
dc.description.sponsorship | Ministerio de Economia y Competitividad PSI2012-32077 | es |
dc.description.sponsorship | Ministerio de Economia y Competitividad PSI2015-64965-P/MINECO-FEDER, UE | es |
dc.description.sponsorship | Instituto de Salud Carlos III PI11/02334 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers | es |
dc.relation.ispartof | Frontiers in Behavioral Neurosciences, 10 | |
dc.rights | Atribución-CompartirIgual 4.0 Internacional | * |
dc.rights | Attribution-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nd/4.0/ | * |
dc.subject | Schizophrenia | es |
dc.subject | Biomarker | es |
dc.subject | Prepulse inhibition | es |
dc.subject | Startle | es |
dc.subject | Endophenotype | es |
dc.subject | Habituation | es |
dc.title | Reduced Prepulse Inhibition as a Biomarker of Schizophrenia | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psicología Experimental | es |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/PSI2015-64965-P | es |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/PSI2012-32077 | es |
dc.relation.projectID | PI11/02334 | es |
dc.relation.publisherversion | http://journal.frontiersin.org/article/10.3389/fnbeh.2016.00202/full | es |
dc.identifier.doi | http://dx.doi.org/ 10.3389/fnbeh.2016.00202 | es |
dc.contributor.group | Universidad de Sevilla. HUM646: Aprendizaje y cognición | es |
idus.format.extent | 9 p. | es |
dc.journaltitle | Frontiers in Behavioral Neuroscience | es |
dc.publication.volumen | 10 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/47846 | |