Síntesis del 2-amino-2-desoxi-d-glicero-d-ido-heptononitrilo y de algunos de sus derivados

Abstract

Treatment of a suspension of !l-0-glucopyranosylamine in pyridine with dry hydro­ gen cyanide affords, at room temperature. in good yield, 2-amino-2 -deoxy-O·g/ycero·O·ido· heptononitrile (1). The structure of 1 is assigned on the basis of spectroscopic and chemical methods. Benzoylation of 1 gives the hexabenzoy l derivative 11. and treatment of 1 with benzyl chlorocarbo nate, yields the 2-benzyloxycarbonylamino-2 -deoxy- D-g/ycero-D-ido -heptononitrile (111).