dc.creator | Rabasco Álvarez, Antonio María | |
dc.creator | López Cacho, José Manuel | |
dc.creator | González Rodríguez, Pedro Luis | |
dc.creator | Talero Barrientos, Beatriz | |
dc.creator | González Rodríguez, María Luisa | |
dc.date.accessioned | 2016-01-18T12:17:30Z | |
dc.date.available | 2016-01-18T12:17:30Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1537-744X | es |
dc.identifier.uri | http://hdl.handle.net/11441/32756 | |
dc.description.abstract | Formulation process is a very complex activity which sometimes implicates taking decisions about parameters or variables to
obtain the best results in a high variability or uncertainty context. Therefore, robust optimization tools can be very useful for
obtaining high quality formulations. This paper proposes the optimization of different responses through the robust Taguchi
method. Each response was evaluated like a noise variable, allowing the application of Taguchi techniques to obtain a response
under the point of view of the signal to noise ratio. A L18 Taguchi orthogonal array design was employed to investigate the
effect of eight independent variables involved in the formulation of alginate-Carbopol beads. Responses evaluated were related
to drug release profile from beads (t50% and AUC), swelling performance, encapsulation efficiency, shape and size parameters.
Confirmation tests to verify the prediction model were carried out and the obtained results were very similar to those predicted in
every profile. Results reveal that the robust optimization is a very useful approach that allows greater precision and accuracy to the
desired value. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Hindawi Publishing Corporation | es |
dc.relation.ispartof | The Scientific World Journal, (2012), 1-15 | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | alginic acid | es |
dc.subject | carbopol 940 | es |
dc.subject | methylene blue | es |
dc.subject | acrylic acid resin | es |
dc.subject | polymer | es |
dc.subject | accuracy | es |
dc.subject | Taguchi orthogonal array design | es |
dc.subject | drug delivery system | es |
dc.title | Robust optimization of alginate-Carbopol 940 bead formulations | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Organización Industrial y Gestión de Empresas I | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Organización Industrial y Gestión de Empresas II | es |
dc.relation.publisherversion | doi:10.1100/2012/605610 | es |
dc.identifier.doi | http://dx.doi.org/10.1100/2012/605610 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/32756 | |