Artículo
Microneedle array-based electrochemical sensor functionalized with SWCNTs for the highly sensitive monitoring of MDMA in interstitial fluid
Autor/es | Drăgan, Ana Maria
Parrilla, Marc Cambré, Sofie Domínguez Robles, Juan Detamornrat, Usanee Donnelly, Ryan F. Oprean, Radu Cristea, Cecilia De Wael, Karolien |
Departamento | Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica |
Fecha de publicación | 2023-10 |
Fecha de depósito | 2024-09-12 |
Publicado en |
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Resumen | Illicit drug consumption constitutes a great concern worldwide due to its increased spread and abuse, and the negative consequences exerted on society. For instance, 3,4-methylenedioxymethamphetamine (MDMA), a synthetic ... Illicit drug consumption constitutes a great concern worldwide due to its increased spread and abuse, and the negative consequences exerted on society. For instance, 3,4-methylenedioxymethamphetamine (MDMA), a synthetic amphetamine-type substance, was abused by 20 million people worldwide in 2020. This psychoactive substance exerts a myriad of effects on the human body being dangerous for the consumer’s health. Besides, MDMA has been used in the treatment of some psychiatric conditions. Therefore, the development of wearable devices for MDMA sensing in biological fluids is of great importance for forensic toxicology (e.g., monitoring of patients with suspected or known MDMA consumption) as well as for therapeutic management of patients. Herein, we report the development of a wearable electrochemical platform based on a hollow microneedle (MN) array sensor for the monitoring of MDMA in the interstitial fluid by square-wave voltammetry. First, the holes of the MN array were modified with conductive pastes to devise a MN patch with a three-electrode system. Subsequently, the functionalization of the working electrode with nanomaterials enhanced MDMA detection. Thereafter, analytical parameters were evaluated exhibiting a slope of 0.05 µA µM−1 within a linear range from 1 to 50 µM and a limit of detection of 0.75 µM in artificial interstitial fluid. Importantly, critical parameters such as selectivity, piercing capability, temperature, reversibility and stability were assessed. Overall, the obtained MN sensor exhibited excellent analytical performance, making it a promising tool for MDMA tracking in interstitial fluid for individuals on probation or under therapeutic treatment. |
Agencias financiadoras | European Union (UE) Engineering and Physical Sciences Research Council (UK) Fund for Scientific Research (FWO). Belgium Ministerio de Ciencia e Innovación (MICIN). España |
Identificador del proyecto | 833787
EP/H021647/1 K217022N 1265223N RYC-2021-034357-I |
Cita | Drăgan, A.M., Parrilla, M., Cambré, S., Domínguez Robles, J., Detamornrat, U., Donnelly, R.F.,...,De Wael, K. (2023). Microneedle array-based electrochemical sensor functionalized with SWCNTs for the highly sensitive monitoring of MDMA in interstitial fluid. Microchemical Journal, 193, 109257. https://doi.org/10.1016/j.microc.2023.109257. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Microneedle array-based_C.pdf | 1.391Mb | [PDF] | Ver/ | Versión aceptada |