dc.creator | Nils, Heilyn Joanna | es |
dc.creator | Arce Recatala, Cristina | es |
dc.creator | Castaño Seiquer, Antonio Luis | es |
dc.creator | Ribas Pérez, David | es |
dc.creator | Flores-Fraile, Javier | es |
dc.date.accessioned | 2024-07-22T07:43:52Z | |
dc.date.available | 2024-07-22T07:43:52Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Nils, H.J., Arce Recatala, C., Castaño Seiquer, A.L., Ribas Pérez, D. y Flores-Fraile, J. (2023). Efficacy/Safety of the Use of Glucocorticoids in Oral and Maxillofacial Surgery. Dentistry journal, 11 (10), 239. https://doi.org/10.3390/dj11100239. | |
dc.identifier.issn | 2304-6767 | es |
dc.identifier.uri | https://hdl.handle.net/11441/161587 | |
dc.description.abstract | Introduction: Glucocorticoids, also known as corticosteroids or steroids, are drugs derived
from cholesterol. They are synthesized by the adrenal cortex, along with other hormones, such as
cortisol and aldosterone. Glucocorticoids are drugs recommended for patients undergoing surgery
on the oral cavity, facial skeleton, and related cervical structures due to their high efficacy against
inflammatory and immune processes. However, these drugs are restricted due to their multiple
and serious adverse effects. The objective of this study was to verify the efficacy of corticosteroids
administered in major surgeries of the oral cavity, as well as of the cervical and facial structures, based
on the characteristics of the patient so as to select the best therapeutic strategy. Methods: Articles in
the databases of PubMed, Nature Portfolio, Medline, Cochrane Library, and Google Scholar were
thoroughly examined. Results: A total of 54 articles were selected to address the proposed objectives.
The results obtained show that it is effective and safe to use glucocorticoids as pre- or postsurgical
therapy in oral and maxillofacial surgery to control the processes of inflammation, pain, lockjaw,
and edema. However, when referring to the use of these drugs, one must proceed with caution and
pay particular attention when handling them. The concentration of the glucocorticoids used must
be individualized, as well as the selection of the route of administration. Various studies show that,
although the oral route is the most used route, the most effective route is the intramuscular route due
to its easy absorption. However, for patients who have recurrent inflammatory and vesiculobullous
ulcerative lesions, the topical route should be chosen to mitigate side effects, considering that
recurrent applications must be made to prevent the worsening of the lesion and to avoid having to
use medications enterally. In patients with cervicofacial infections, antibiotics continue to be the main
drugs used to manage the condition in conjunction with corticosteroids. It is important to know the
possible interactions of glucocorticoids with other medicines or food: it has been described that the
interaction between Ritonavir, an antiretroviral drug that inhibits human immunodeficiency virus
(HIV) proteases, and prednisone causes an increase in the concentration of prednisone, leading to
possible toxicity in normally safe doses and, in many cases, iatrogenic Cushing’s syndrome. It is
also important to know the systemic or topical adverse effects of the chronic or high-dose use of
glucocorticoids. Conclusions: It can be concluded that by making adequate use of glucocorticoid
therapy in oral and maxillofacial surgery to manage clinical manifestations, it is possible to attenuate
the morbidities of treatment and intervention. | es |
dc.format | application/pdf | es |
dc.format.extent | 20 p. | es |
dc.language.iso | eng | es |
dc.publisher | Mdpi | es |
dc.relation.ispartof | Dentistry journal, 11 (10), 239. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Corticosteroids | es |
dc.subject | Anti-inflammatory postoperative oral surgery | es |
dc.subject | Dexamethasone | es |
dc.subject | Dentistry | es |
dc.subject | Dosage form design | es |
dc.subject | Route of administration | es |
dc.subject | Cervicofacial infection | es |
dc.title | Efficacy/Safety of the Use of Glucocorticoids in Oral and Maxillofacial Surgery | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estomatología | es |
dc.relation.publisherversion | https://www.mdpi.com/2304-6767/11/10/239 | es |
dc.identifier.doi | 10.3390/dj11100239 | es |
dc.journaltitle | Dentistry journal | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 10 | es |
dc.publication.initialPage | 239 | es |