Show simple item record

Article

dc.creatorGeorgina-Pérez, Lauraes
dc.creatorRibas Pérez, Davides
dc.creatorDehesa-Santos, Alexandraes
dc.creatorMendoza Mendoza, María Asunciónes
dc.date.accessioned2024-06-24T14:59:56Z
dc.date.available2024-06-24T14:59:56Z
dc.date.issued2023-04-30
dc.identifier.citationGeorgina-Pérez, L., Ribas Pérez, D., Dehesa-Santos, A. y Mendoza Mendoza, M.A. (2023). Relationship between the TGFBR1 Gene and Molar Incisor Hypomineralization. Journal of personalized medicine. https://doi.org/10.3390/jpm13050777.
dc.identifier.issn2075-4426es
dc.identifier.urihttps://hdl.handle.net/11441/160824
dc.description.abstractBackground: Molar Incisor Hypomineralization Syndrome (MIH) is a problem of increasing incidence that represents a new challenge in the dental treatment of many of the children we see in our dental offices. Understanding the etiology of this syndrome (still unknown) will help us to prevent the appearance of this process. Lately a certain genetic relationship has been suggested in the syndrome. The aim of the present study was to explore the relationship between activation of the TGFBR1 gene and the development of MIH, as recent studies suggest that there may be an association in this regard. Materials and Methods: The study sample consisted of 50 children between 6–17 years of age with MIH, each with at least one parent and a sibling with or without MIH, and a group control of 100 children without MIH. The condition of the permanent molars and incisors was evaluated and recorded based on the criteria of Mathu-Muju and Wright. Saliva samples were collected after washing and rinsing of the oral cavity. Genotyping was performed with the saliva samples for the selection of a target polymorphism of the studied gene (TGFBR1). Results: The mean age was 9.7 years (SD 2.36). Of the 50 children with MIH, 56% were boys and 44% girls. The degree of MIH was predominantly severe (58%), with moderate and mild involvement in 22% and 20% of the cases, respectively, according to the classification of Mathu-Muju. The allelic frequencies were seen to behave as expected. The logistic regression analysis aimed to relate each polymorphism to the presence or absence of the factors. These results were inconclusive, with no evidence suggesting an alteration of the TGFBR1 gene to be related to the appearance of MIH. Conclusions: Within the limitations posed by a study of these characteristics, it can be affirmed that no relationship has been found between the TGFBR1 gene and the appearance of molar incisor hypomineralization.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofJournal of personalized medicine.
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMolar incisor hypomineralizationes
dc.subjectGenetic relationshipes
dc.subjectTGFBR1 genees
dc.titleRelationship between the TGFBR1 Gene and Molar Incisor Hypomineralizationes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Estomatologíaes
dc.relation.publisherversionhttps://www.mdpi.com/2075-4426/13/5/777es
dc.identifier.doi10.3390/jpm13050777es
dc.journaltitleJournal of personalized medicinees
dc.publication.volumen13
dc.publication.issue5
dc.publication.initialPage777

FilesSizeFormatViewDescription
Relationship...pdf930.2KbIcon   [PDF] View/Open  

This item appears in the following collection(s)

Show simple item record

Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as: Atribución 4.0 Internacional