dc.creator | González Sánchez, Manuela | es |
dc.creator | Zamora Ledezma, Camilo | es |
dc.creator | Elango, Jeevithan | es |
dc.creator | Morales Flórez, Víctor | es |
dc.date.accessioned | 2024-06-20T14:24:53Z | |
dc.date.available | 2024-06-20T14:24:53Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | González Sánchez, M., Zamora Ledezma, C., Elango, J. y Morales Flórez, V. (2024). Novel Bioactive and Biocompatible Alumina-wollastonite Porous Constructs Mimicking Physical Properties of Human Cortical Bone. Journal of the European Ceramic Society, 44 (7), 4699-4708. https://doi.org/10.1016/j.jeurceramsoc.2024.02.001. | |
dc.identifier.issn | 0955-2219 | es |
dc.identifier.issn | 1873-619X | es |
dc.identifier.uri | https://hdl.handle.net/11441/160737 | |
dc.description.abstract | A new procedure for the bioactivation of alumina-based porous ceramic constructs was introduced. The constructs were built with the aim of mimicking the structural and mechanical properties of the human cortical bone. Bioactivation was achieved by adding wollastonite and acidic surface treatment (piranha solution). Structural studies (SEM, CAT) confirmed that adequate pore size and interconnectivity were obtained. Uniaxial compression tests showed that the values of Young's moduli and compressive strength were reduced, from 5 to 1 GPa, and from 45 to 15 MPa, respectively, as the wollastonite content increased from 0 to 40 wt.%. Proliferative, histological and fluorescence results confirmed that cell proliferation rate of bone-marrow-derived mesenchymal stem cells were significantly enhanced by increasing wollastonite content. No cytotoxic effect was observed. In summary, the fabricated bioceramics exhibited suggestive structural and mechanical properties and they could be useful for the practical bone tissue engineering applications without any adverse biological effects. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PGC2018-094952-B-I00 | es |
dc.description.sponsorship | Junta de Andalucía P20-01121 | es |
dc.description.sponsorship | Universidad de Sevilla 2023/00000372 | es |
dc.description.sponsorship | Universidad Católica San Antonio de Murcia PMAFI-27/21, PMAFI-12/21 | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Journal of the European Ceramic Society, 44 (7), 4699-4708. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Alumina-wollastonite bioceramics | es |
dc.subject | Bioactivation | es |
dc.subject | Cell proliferation | es |
dc.subject | Mechanical properties | es |
dc.subject | Porous structure | es |
dc.title | Novel Bioactive and Biocompatible Alumina-wollastonite Porous Constructs Mimicking Physical Properties of Human Cortical Bone | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Física de la Materia Condensada | es |
dc.relation.projectID | PGC2018-094952-B-I00 | es |
dc.relation.projectID | P20-01121 | es |
dc.relation.projectID | 2023/00000372 | es |
dc.relation.projectID | PMAFI-27/21 | es |
dc.relation.projectID | PMAFI-12/21 | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.jeurceramsoc.2024.02.001 | es |
dc.identifier.doi | 10.1016/j.jeurceramsoc.2024.02.001 | es |
dc.journaltitle | Journal of the European Ceramic Society | es |
dc.publication.volumen | 44 | es |
dc.publication.issue | 7 | es |
dc.publication.initialPage | 4699 | es |
dc.publication.endPage | 4708 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | Universidad de Sevilla | es |
dc.contributor.funder | Universidad Católica San Antonio de Murcia (UCAM) | es |