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Doped electrospinned material-guides high efficiency regional bone regeneration
dc.creator | Toledano, Manuel | es |
dc.creator | Vallecillo, Cristina | es |
dc.creator | Serrera Figallo, María de los Ángeles | es |
dc.creator | Vallecillo-Rivas, Marta | es |
dc.creator | Gutiérrez Corrales, Aída | es |
dc.creator | Lynch, Christopher D. | es |
dc.creator | Toledano-Osorio, Manuel | es |
dc.date.accessioned | 2024-06-19T12:49:32Z | |
dc.date.available | 2024-06-19T12:49:32Z | |
dc.date.issued | 2023-03-30 | |
dc.identifier.citation | Toledano, M., Vallecillo, C., Serrera Figallo, M.d.l.Á., Vallecillo-Rivas, M., Gutiérrez Corrales, A., Lynch, C.D. y Toledano-Osorio, M. (2023). Doped electrospinned material-guides high efficiency regional bone regeneration. Plymers, 15 (7), 1726. https://doi.org/10.3390/polym15071726. | |
dc.identifier.issn | 2073-4360 | es |
dc.identifier.uri | https://hdl.handle.net/11441/160691 | |
dc.description.abstract | The main target of bone tissue engineering is to design biomaterials that support bone regeneration and vascularization. Nanostructured membranes of (MMA)1-co-(HEMA)1/(MA)3- co-(HEA)2 loaded with 5% wt of SiO2 -nanoparticles (Si-M) were doped with zinc (Zn-Si-M) or doxycycline (Dox-Si-M). Critical bone defects were effectuated on six New Zealand-bred rabbit skulls and then they were covered with the membranes. After six weeks, a histological analysis (toluidine blue technique) was employed to determine bone cell population as osteoblasts, osteoclasts, osteocytes, M1 and M2 macrophages and vasculature. Membranes covering the bone defect determined a higher count of bone cells and blood vessels than in the sham group at the top regions of the defect. Pro-inflammatory M1 appeared in a higher number in the top regions than in the bottom regions, when Si-M and Dox-Si-M were used. Samples treated with Dox-Si-M showed a higher amount of anti-inflammatory and pro-regenerative M2 macrophages. The M1/M2 ratio obtained its lowest value in the absence of membranes. On the top regions, osteoblasts were more abundant when using Si-M and Zn-Si-M. Osteoclasts were equally distributed at the central and lateral regions. The sham group and samples treated with Zn-Si-M attained a higher number of osteocytes at the top regions. A preferential osteoconductive, osteoinductive and angiogenic clinical environment was created in the vicinity of the membrane placed on critical bone defects. | es |
dc.format | application/pdf | es |
dc.format.extent | 21 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Plymers, 15 (7), 1726. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Zinc | es |
dc.subject | Doxycycline | es |
dc.subject | Silica | es |
dc.subject | Regeneration | es |
dc.subject | Bone cells | es |
dc.subject | Polymer | es |
dc.subject | Membrane | es |
dc.subject | Vascularization | es |
dc.subject | Macrophage | es |
dc.title | Doped electrospinned material-guides high efficiency regional bone regeneration | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estomatología | es |
dc.relation.publisherversion | https://www.mdpi.com/2073-4360/15/7/1726 | es |
dc.identifier.doi | 10.3390/polym15071726 | es |
dc.journaltitle | Plymers | es |
dc.publication.volumen | 15 | es |
dc.publication.issue | 7 | es |
dc.publication.initialPage | 1726 | es |
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