dc.creator | Baus Domínguez, María | es |
dc.creator | Aguilera, Felipe-Rodrigo | es |
dc.creator | Vivancos-Cuadras, Fernando | es |
dc.creator | Ferra-Domingo, Lourdes | es |
dc.creator | Torres-Lagares, Daniel | es |
dc.creator | Gutiérrez Pérez, José Luis | es |
dc.creator | Pereira-Riveros, Tanya | es |
dc.creator | Serrera Figallo, María de los Ángeles | es |
dc.date.accessioned | 2024-06-18T12:59:45Z | |
dc.date.available | 2024-06-18T12:59:45Z | |
dc.date.issued | 2023-12-23 | |
dc.identifier.citation | Baus Domínguez, M., Aguilera, F., Vivancos-Cuadras, F., Ferra-Domingo, L., Torres-Lagares, D., Gutiérrez Pérez, J.L.,...,Serrera Figallo, M.d.l.Á. (2023). Mucoadhesive Pharmacology: Latest Clinical Technology in Antiseptic Gels. Gels, 10 (1), 23. https://doi.org/10.3390/gels10010023. | |
dc.identifier.issn | 2310-2861 | es |
dc.identifier.uri | https://hdl.handle.net/11441/160644 | |
dc.description.abstract | Chlorhexidine (CHX) is one of the most widely used antiseptics in the oral cavity due to its
high antimicrobial potential. However, many authors have stated that the effect of CHX in nonsurgical
periodontal therapy is hampered by its rapid elimination from the oral environment. The aim of
this study was to determine the antibacterial efficacy of a new compound of chlorhexidine 0.20%
+ cymenol (CYM) 0.10% on a multispecies biofilm. For this, an in vitro study was designed using
a multispecies biofilm model of Streptococcus mutans, Fusobacterium nucleatum, Prevotella intermedia,
and Porphyromonas gingivalis. Quantification of the microbial viability of the biofilm was performed
using 5-cyano-2,3-ditolyl tetrazolium-chloride (CTC) to calculate the percentage of survival, and
the biofilms were observed using a a confocal laser scanning microscopy (CLSM). It was observed
that the bactericidal activity of the CHX + cymenol bioadhesive gel was superior to that of the CHX
bioadhesive gel, in addition to higher penetrability into the biofilm. Therefore, there was greater
elimination of bacterial biofilm with the new compound of chlorhexidine 0.2% plus cymenol 0.1% in
a bioadhesive gel form compared to the formulation with only chlorhexidine 0.2% in a bioadhesive
gel form. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Gels, 10 (1), 23. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Antimicrobial gels | es |
dc.subject | Chlorhexidine | es |
dc.subject | Cymenol | es |
dc.subject | Periodontal application | es |
dc.subject | Substantivity | es |
dc.subject | Antibacterial gels | es |
dc.title | Mucoadhesive Pharmacology: Latest Clinical Technology in Antiseptic Gels | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estomatología | es |
dc.relation.publisherversion | https://www.mdpi.com/2310-2861/10/1/23 | es |
dc.identifier.doi | 10.3390/gels10010023 | es |
dc.journaltitle | Gels | es |
dc.publication.volumen | 10 | |
dc.publication.issue | 1 | |
dc.publication.initialPage | 23 | |