Artículo
The Efficacy and Safety of Rebamipide Ophthalmic Suspension (OPC-12759) in Patients with Dry Eye Disease: A Systematic Review of Randomized Controlled Trials
Autor/es | Ballesteros Sánchez, Antonio
Sánchez González, María del Carmen ![]() ![]() ![]() ![]() ![]() ![]() ![]() Hita Cantalejo, María Concepción de ![]() ![]() ![]() ![]() ![]() ![]() ![]() Gutiérrez Sánchez, Estanislao ![]() ![]() ![]() ![]() ![]() Rocha de Lossada, Carlos ![]() ![]() ![]() ![]() ![]() Sánchez González, José María ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Departamento | Universidad de Sevilla. Departamento de Física de la Materia Condensada Universidad de Sevilla. Departamento de Cirugía |
Fecha de publicación | 2023 |
Fecha de depósito | 2024-06-04 |
Publicado en |
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Resumen | The aim of this paper is to evaluate the efficacy and safety of Rebamipide (REB) ophthalmic suspension in dry eye disease (DED). A systematic review that only included full-length randomized controlled studies (RCTs) ... The aim of this paper is to evaluate the efficacy and safety of Rebamipide (REB) ophthalmic suspension in dry eye disease (DED). A systematic review that only included full-length randomized controlled studies (RCTs) reporting the effects of REB ophthalmic suspension in three databases, PubMed, Scopus and Web of Science, was performed according to the PRISMA statement. The Cochrane risk of bias tool was used to analyze the quality of the studies selected. A total of seven studies were included in this systematic review. Although the overall risk of bias was low, most studies were sponsored by the manufacturer. REB ophthalmic suspension treatment achieved higher improvement than the control group in all reported variables. The mean differences between both groups were in favor of the REB group and were as follows: dry eye-related quality of life score (DEQS) -3.5 +- 2.9 points, tear film break-up time (TBUT) of 0.7 +- 0.6 s, Schirmer test (ST) without anesthesia of 0.3 +- 0.6 mm and total corneal fluorescein staining (tCFS) of -1.2 +- 0.7 points. Adverse events (AEs) were 5.2 +- 7.6% superior in the REB group, with an overall compliance > 95%. Therefore, REB ophthalmic suspension is a safe and effective treatment that could be recommended in patients with DED. |
Cita | Ballesteros Sánchez, A., Sánchez González, M.d.C., Hita Cantalejo, M.C.d., Gutiérrez Sánchez, E., Rocha de Lossada, C. y Sánchez González, J.M. (2023). The Efficacy and Safety of Rebamipide Ophthalmic Suspension (OPC-12759) in Patients with Dry Eye Disease: A Systematic Review of Randomized Controlled Trials. Journal of Clinical Medicine, 12 (22), 7155. https://doi.org/10.3390/ jcm12227155. |
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