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dc.creatorBallesteros Sánchez, Antonioes
dc.creatorSánchez González, José Maríaes
dc.creatorTedesco, Giovanni Robertoes
dc.creatorRocha de Lossada, Carloses
dc.creatorRusso, Fedelees
dc.creatorSpinelli, Antonioes
dc.creatorIngrande, Irenees
dc.creatorBorroni, Davidees
dc.date.accessioned2024-06-03T15:33:31Z
dc.date.available2024-06-03T15:33:31Z
dc.date.issued2024-02
dc.identifier.citationBallesteros Sánchez, A., Sánchez González, J.M., Tedesco, G.R., Rocha de Lossada, C., Russo, F., Spinelli, A.,...,Borroni, D. (2024). Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Patients with Aqueous-Deficient, Evaporative and Mixed-Type Dry Eye: A Randomized Interventional Study. Ophthalmology and Therapy, 13 (2), 495-507. https://doi.org/10.1007/s40123-023-00868-w.
dc.identifier.issn2193-8245es
dc.identifier.issn2193-6528es
dc.identifier.urihttps://hdl.handle.net/11441/159625
dc.description.abstractIntroduction: To evaluate the efficacy and safety of Quantum Molecular Resonance (QMR) treatment in patients with severe dry eye disease (DED), as well as its effects on aqueous-deficient (ADDE), evaporative (EDE), and mixed (MDE) dry eye. Methods: In this prospective, interventional study, 81 patients were randomly allocated to received four treatment sessions of QMR at 1-week intervals (Rexon-Eye®, Resono Ophthalmic, Trieste, Italy) (QRM group) or tear substitute four times daily, containing 0.15% sodium hyaluronate and 3% trehalose (Thealoz Duo®, Thea Pharma, France) (SH-TH group). Outcome measures included ocular surface disease index (OSDI) questionnaire, tear meniscus height (TMH), tear breakup time (TBUT), non-invasive breakup time (NIBUT), corneal fluorescein staining (CFS), lipid layer thickness (LLT), tear film osmolarity (OSM), and meibomian gland dysfunction (MGD) grade, which were assessed at baseline and 1-month and 3-month follow-up. Results: The QMR group achieved better improvements than the SH-TH group in OSDI and SANDE questionnaires, NIBUT, LLT, and CFS. The mean differences between the groups were as follows: OSDI (− 12.4 ± 0.25 points, P = 0.01), SANDE (10.6 ± 1.7 points, P = 0.01), NIBUT (2 ± 0.25 s, P = 0.01), LLT (18.7 ± 0.7 nm, P = 0.01), and CFS (1.2 ± 0.1 points, P = 0.02). In subgroups analysis, QMR treatment demonstrated a beneficial role to improve DED symptoms and signs in ADDE, EDE, and MDE. Conclusion: QMR is an effective and well-tolerated treatment that seems to improve DED symptoms and signs in patients with severe DED. However, further studies are needed to confirm this. Trial Registration: ClinicalTrials.gov identifier NCT06119386.es
dc.formatapplication/pdfes
dc.format.extent13 p.es
dc.language.isoenges
dc.publisherSpringer Naturees
dc.relation.ispartofOphthalmology and Therapy, 13 (2), 495-507.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAqueous-deficient dry eyees
dc.subjectDry eye diseasees
dc.subjectEvaporative dry eyees
dc.subjectMeibomian gland dysfunctiones
dc.subjectMixed dry eyees
dc.subjectQuantum Molecular Resonance electrotherapyes
dc.titleEfficacy and Safety of Quantum Molecular Resonance Electrotherapy in Patients with Aqueous-Deficient, Evaporative and Mixed-Type Dry Eye: A Randomized Interventional Studyes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Física de la Materia Condensadaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Cirugíaes
dc.relation.publisherversionhttps://doi.org/10.1007/s40123-023-00868-wes
dc.identifier.doi10.1007/s40123-023-00868-wes
dc.journaltitleOphthalmology and Therapyes
dc.publication.volumen13es
dc.publication.issue2es
dc.publication.initialPage495es
dc.publication.endPage507es

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