dc.creator | Ballesteros Sánchez, Antonio | es |
dc.creator | Sánchez González, José María | es |
dc.creator | Tedesco, Giovanni Roberto | es |
dc.creator | Rocha de Lossada, Carlos | es |
dc.creator | Russo, Fedele | es |
dc.creator | Spinelli, Antonio | es |
dc.creator | Ingrande, Irene | es |
dc.creator | Borroni, Davide | es |
dc.date.accessioned | 2024-06-03T15:33:31Z | |
dc.date.available | 2024-06-03T15:33:31Z | |
dc.date.issued | 2024-02 | |
dc.identifier.citation | Ballesteros Sánchez, A., Sánchez González, J.M., Tedesco, G.R., Rocha de Lossada, C., Russo, F., Spinelli, A.,...,Borroni, D. (2024). Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Patients with Aqueous-Deficient, Evaporative and Mixed-Type Dry Eye: A Randomized Interventional Study. Ophthalmology and Therapy, 13 (2), 495-507. https://doi.org/10.1007/s40123-023-00868-w. | |
dc.identifier.issn | 2193-8245 | es |
dc.identifier.issn | 2193-6528 | es |
dc.identifier.uri | https://hdl.handle.net/11441/159625 | |
dc.description.abstract | Introduction: To evaluate the efficacy and safety of Quantum Molecular Resonance (QMR) treatment in patients with severe dry eye disease (DED), as well as its effects on aqueous-deficient (ADDE), evaporative (EDE), and mixed (MDE) dry eye. Methods: In this prospective, interventional study, 81 patients were randomly allocated to received four treatment sessions of QMR at 1-week intervals (Rexon-Eye®, Resono Ophthalmic, Trieste, Italy) (QRM group) or tear substitute four times daily, containing 0.15% sodium hyaluronate and 3% trehalose (Thealoz Duo®, Thea Pharma, France) (SH-TH group). Outcome measures included ocular surface disease index (OSDI) questionnaire, tear meniscus height (TMH), tear breakup time (TBUT), non-invasive breakup time (NIBUT), corneal fluorescein staining (CFS), lipid layer thickness (LLT), tear film osmolarity (OSM), and meibomian gland dysfunction (MGD) grade, which were assessed at baseline and 1-month and 3-month follow-up. Results: The QMR group achieved better improvements than the SH-TH group in OSDI and SANDE questionnaires, NIBUT, LLT, and CFS. The mean differences between the groups were as follows: OSDI (− 12.4 ± 0.25 points, P = 0.01), SANDE (10.6 ± 1.7 points, P = 0.01), NIBUT (2 ± 0.25 s, P = 0.01), LLT (18.7 ± 0.7 nm, P = 0.01), and CFS (1.2 ± 0.1 points, P = 0.02). In subgroups analysis, QMR treatment demonstrated a beneficial role to improve DED symptoms and signs in ADDE, EDE, and MDE. Conclusion: QMR is an effective and well-tolerated treatment that seems to improve DED symptoms and signs in patients with severe DED. However, further studies are needed to confirm this. Trial Registration: ClinicalTrials.gov identifier NCT06119386. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer Nature | es |
dc.relation.ispartof | Ophthalmology and Therapy, 13 (2), 495-507. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Aqueous-deficient dry eye | es |
dc.subject | Dry eye disease | es |
dc.subject | Evaporative dry eye | es |
dc.subject | Meibomian gland dysfunction | es |
dc.subject | Mixed dry eye | es |
dc.subject | Quantum Molecular Resonance electrotherapy | es |
dc.title | Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Patients with Aqueous-Deficient, Evaporative and Mixed-Type Dry Eye: A Randomized Interventional Study | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Física de la Materia Condensada | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.relation.publisherversion | https://doi.org/10.1007/s40123-023-00868-w | es |
dc.identifier.doi | 10.1007/s40123-023-00868-w | es |
dc.journaltitle | Ophthalmology and Therapy | es |
dc.publication.volumen | 13 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 495 | es |
dc.publication.endPage | 507 | es |