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dc.creatorFerrero Rodríguez, Carmenes
dc.creatorUrpí, Lourdeses
dc.creatorAguilar de Leyva, Mercedes Ángelaes
dc.creatorMora Castaño, Gloriaes
dc.creatorLinares Blasco, Vicentees
dc.creatorMillán Jiménez, Mónicaes
dc.creatorMartínez de Ilarduya, Antxones
dc.creatorCaraballo Rodríguez, Isidoroes
dc.date.accessioned2024-06-03T11:17:51Z
dc.date.available2024-06-03T11:17:51Z
dc.date.issued2024
dc.identifier.citationFerrero Rodríguez, C., Urpí, L., Aguilar de Leyva, M.Á., Mora Castaño, G., Linares Blasco, V., Millán Jiménez, M.,...,Caraballo Rodríguez, I. (2024). Application of ultrasound-assisted compression and 3D-printing semi-solid extrusion techniques to the development of sustained-release drug delivery systems based on a novel biodegradable aliphatic copolyester. Journal of Drug Delivery Science and Technology, 95, 105652. https://doi.org/10.1016/j.jddst.2024.105652.
dc.identifier.issn1773-2247es
dc.identifier.urihttps://hdl.handle.net/11441/159614
dc.description.abstractThe purpose of this study was to investigate the ability of two advanced hot-processing technologies, Ultrasound-Assisted Compression (USAC) and 3D-printing Semi-solid Extrusion (SSE), to manufacture sustained-release drug delivery systems based on a novel biodegradable aliphatic copolyester. The copolymer was synthesized from ω-pentadecalactone (PDL), 1,4-cyclohexanedimethanol (CHDM) and dimethyl succinate (DMS) (monomer ratio PDL/CHDM/DMS 70/30/30) by enzymatic ring opening polymerization and two-step melt polycondensation processes and has a random microstructure, a high molecular weight (107,100 g mol -1) and a relatively low melting point (~65 ◦C). The antibacterial agent metronidazole (MTZ) was chosen as model drug and binary physical mixtures copolymer:drug were prepared at 90:10 and 70:30 w/w ratios. Thermal analysis studies evidenced that the formulations could be processed below their degradation temperatures. Drug delivery devices with dense and meshed structures were manufactured using USAC and SSE techniques, respectively, with USAC devices exhibiting more reproducible physical properties than the SSE systems. Powder X-ray diffraction and scanning electron microscopy studies showed a partial sintering of the copolyester during USAC processing while MTZ remained mostly crystalline. In contrast, the copolymer melted and the drug underwent some amorphization when processed using SSE. In vitro drug release studies in phosphate buffer (pH 6.8) showed that, after an initial burst release of metronidazole, USAC and SSE devices exhibited a prolonged and/or sustained drug release over 20 days. The initial burst release was dependent on the manufacturing technique and the drug/polymer ratio, being minimized for SSE devices containing 10 wt% MTZ. The whole drug release profiles fitted well to the Peppas-Sahlin model, being drug diffusion the predominant release mechanism. After the burst release, the sustained release period of USAC and SSE devices containing 10 wt% MTZ showed a good fit to the zero-order kinetic model, with faster drug release from the SSE devices due to the larger surface area of their meshed structure. In conclusion, this work demonstrates that processing the aliphatic copolyester by both USAC and SSE technologies provides an attractive strategy to manufacture biodegradable drug delivery systems for long-term release of metronidazole.es
dc.description.sponsorshipMCIN/AEI/10.13039/501100011033 and by ERDF RTI2018-095041-BC31es
dc.formatapplication/pdfes
dc.format.extent12 p.es
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofJournal of Drug Delivery Science and Technology, 95, 105652.
dc.rightsAttribution 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAliphatic copolyesteres
dc.subjectUltrasound-assisted compressiones
dc.subject3D-printing semi-solid extrusiones
dc.subjectMetronidazolees
dc.subjectDrug delivery systemses
dc.subjectSustained-releasees
dc.titleApplication of ultrasound-assisted compression and 3D-printing semi-solid extrusion techniques to the development of sustained-release drug delivery systems based on a novel biodegradable aliphatic copolyesteres
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéuticaes
dc.relation.projectIDRTI2018-095041-BC31es
dc.relation.publisherversionhttps://doi.org/10.1016/j.jddst.2024.105652es
dc.identifier.doi10.1016/j.jddst.2024.105652es
dc.journaltitleJournal of Drug Delivery Science and Technologyes
dc.publication.volumen95es
dc.publication.initialPage105652es
dc.contributor.funderMinisterio de Ciencia e Innovación (MICIN). Españaes
dc.contributor.funderAgencia Estatal de Investigación. Españaes
dc.contributor.funderEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)es

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