dc.creator | Almeida, Tereza | es |
dc.creator | Lopes, Ana M. | es |
dc.creator | Estruch, Josep | es |
dc.creator | Rouco Zufiaurre, Carlos | es |
dc.creator | Cavadini, Patrizia | es |
dc.creator | Neimanis, Aleksija | es |
dc.creator | Abrantes, Joana | es |
dc.date.accessioned | 2024-05-29T16:27:17Z | |
dc.date.available | 2024-05-29T16:27:17Z | |
dc.date.issued | 2024-02-04 | |
dc.identifier.citation | Almeida, T., Lopes, A.M., Estruch, J., Rouco Zufiaurre, C., Cavadini, P., Neimanis, A. y Abrantes, J. (2024). A new HaCV-EBHSV recombinant lagovirus circulating in European brown hares (Lepus europaeus) from Catalonia, Spain. Scientific reports, 14 (1). https://doi.org/10.1038/s41598-024-53201-1. | |
dc.identifier.issn | 2045-2322 | es |
dc.identifier.uri | https://hdl.handle.net/11441/159460 | |
dc.description.abstract | In 2020/2021, several European brown hare syndrome virus (EBHSV) outbreaks were recorded in
European hares (Lepus europaeus) from Catalonia, Spain. Recombination analysis combined with
phylogenetic reconstruction and estimation of genetic distances of the complete coding sequences
revealed that 5 strains were recombinants. The recombination breakpoint is located within the
non-structural protein 2C-like RNA helicase (nucleotide position ~ 1889). For the genomic fragment
upstream of the breakpoint, a non-pathogenic EBHSV-related strain (hare calicivirus, HaCV; GII.2)
was the most closely related sequence; for the rest of the genome, the most similar strains were the
European brown hare syndrome virus (EBHSV) strains recovered from the same 2020/2021 outbreaks,
suggesting a recent origin. While the functional impact of the atypical recombination breakpoint
remains undetermined, the novel recombinant strain was detected in different European brown hare
populations from Catalonia, located 20–100 km apart, and seems to have caused a fatal disease both
in juvenile and adult animals, confirming its viability and ability to spread and establish infection. This
is the first report of a recombination event involving HaCV and EBHSV and, despite the recombination
with a non-pathogenic strain, it appears to be associated with mortality in European brown hares,
which warrants close monitoring. | es |
dc.description.sponsorship | European Union’s Framework Programme for Research and Innovation CEECIND/00078/2017, CEECIND/01388/2017, UIDB/50027/2020 | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación de España PRIMAS2-11-PCI2019-103698 | es |
dc.description.sponsorship | Fundação para a Ciência e a Tecnologia PRIMA/0003/2018 | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language.iso | eng | es |
dc.publisher | Nature Publishing Group | es |
dc.relation.ispartof | Scientific reports, 14 (1). | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | A new HaCV-EBHSV recombinant lagovirus circulating in European brown hares (Lepus europaeus) from Catalonia, Spain | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Vegetal y Ecología | es |
dc.relation.projectID | CEECIND/00078/2017 | es |
dc.relation.projectID | CEECIND/01388/2017 | es |
dc.relation.projectID | UIDB/50027/2020 | es |
dc.relation.projectID | PRIMAS2-11-PCI2019-103698 | es |
dc.relation.projectID | PRIMA/0003/2018 | es |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-024-53201-1 | es |
dc.identifier.doi | 10.1038/s41598-024-53201-1 | es |
dc.journaltitle | Scientific reports | es |
dc.publication.volumen | 14 | es |
dc.publication.issue | 1 | es |
dc.contributor.funder | European Union (UE) | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Fundação para a Ciência e a Tecnologia. Portugal | es |