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Distinct Gastrointestinal and Reproductive Microbial Patterns in Female Holobiont of Infertility
dc.creator | Marcos, Ana T. | es |
dc.creator | Rus, Maria J. | es |
dc.creator | Areal Quecuty, Victoria | es |
dc.creator | Simón-Soro, Aúrea | es |
dc.creator | Navarro-Pando, José Manuel | es |
dc.date.accessioned | 2024-05-23T12:49:40Z | |
dc.date.available | 2024-05-23T12:49:40Z | |
dc.date.issued | 2024-05-14 | |
dc.identifier.citation | Marcos, A.T., Rus, M.J., Areal Quecuty, V., Simón-Soro, A. y Navarro-Pando, J.M. (2024). Distinct Gastrointestinal and Reproductive Microbial Patterns in Female Holobiont of Infertility. Microorganisms, 12 (5). https://doi.org/10.3390/microorganisms12050989. | |
dc.identifier.issn | 2076-2607 | es |
dc.identifier.uri | https://hdl.handle.net/11441/158889 | |
dc.description.abstract | The microbiota is in symbiosis with the human body as a holobiont. Infertility conditions affect the female reproductive tract (FRT) and its resident microbiota. However, a disturbance in homeostasis could influence the FRT and other distal body sites, such as the gastrointestinal tract (GIT). We included 21 patients with endometriosis and other infertility-associated diseases with clinical profiles and biological samples from the FRT (endometrium, endometrial fluid, and vagina), and GIT samples (oral and feces). We performed a 16S rRNA analysis of site-specific microbial communities and estimated diversity metrics. The study found body site-specific microbial patterns in the FRT–GIT. In both study groups, Lactobacillus was the most shared Amplicon Sequence Variant (ASV), a precise identifier of microbial sequences, between endometrial and vagina samples. However, shared Gardnerella and Enterobacteriaceae ASVs were linked to other conditions but not endometriosis. Remarkably, Haemophilus was a specific GIT-shared taxon in endometriosis cases. In conclusion, infertility influences distinctly the FRT and GIT microbiomes, with endometriosis showing unique microbial characteristics. We proposed the concept of ‘female holobiont’ as a community that comprises the host and microbes that must maintain overall homeostasis across all body sites to ensure a woman’s health. Insights into these microbial patterns not only advance our understanding of the pathophysiology of infertility but also open new avenues for developing microbe-based therapeutic interventions aimed at restoring microbial balance, thereby enhancing fertility prospects. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Microorganisms, 12 (5). | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Microbiome | es |
dc.subject | Holobiont | es |
dc.subject | Oral | es |
dc.subject | Tract | es |
dc.subject | Female | es |
dc.subject | Infertility | es |
dc.subject | Endometriosis | es |
dc.title | Distinct Gastrointestinal and Reproductive Microbial Patterns in Female Holobiont of Infertility | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estomatología | es |
dc.relation.publisherversion | https://www.mdpi.com/2076-2607/12/5/989 | es |
dc.identifier.doi | 10.3390/microorganisms12050989 | es |
dc.journaltitle | Microorganisms | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 5 | es |
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Distinct Gastrointestinal...pdf | 2.975Mb | [PDF] | Ver/ | |