Mostrar el registro sencillo del ítem

Artículo

dc.creatorMarcos, Ana T.es
dc.creatorRus, Maria J.es
dc.creatorAreal Quecuty, Victoriaes
dc.creatorSimón-Soro, Aúreaes
dc.creatorNavarro-Pando, José Manueles
dc.date.accessioned2024-05-23T12:49:40Z
dc.date.available2024-05-23T12:49:40Z
dc.date.issued2024-05-14
dc.identifier.citationMarcos, A.T., Rus, M.J., Areal Quecuty, V., Simón-Soro, A. y Navarro-Pando, J.M. (2024). Distinct Gastrointestinal and Reproductive Microbial Patterns in Female Holobiont of Infertility. Microorganisms, 12 (5). https://doi.org/10.3390/microorganisms12050989.
dc.identifier.issn2076-2607es
dc.identifier.urihttps://hdl.handle.net/11441/158889
dc.description.abstractThe microbiota is in symbiosis with the human body as a holobiont. Infertility conditions affect the female reproductive tract (FRT) and its resident microbiota. However, a disturbance in homeostasis could influence the FRT and other distal body sites, such as the gastrointestinal tract (GIT). We included 21 patients with endometriosis and other infertility-associated diseases with clinical profiles and biological samples from the FRT (endometrium, endometrial fluid, and vagina), and GIT samples (oral and feces). We performed a 16S rRNA analysis of site-specific microbial communities and estimated diversity metrics. The study found body site-specific microbial patterns in the FRT–GIT. In both study groups, Lactobacillus was the most shared Amplicon Sequence Variant (ASV), a precise identifier of microbial sequences, between endometrial and vagina samples. However, shared Gardnerella and Enterobacteriaceae ASVs were linked to other conditions but not endometriosis. Remarkably, Haemophilus was a specific GIT-shared taxon in endometriosis cases. In conclusion, infertility influences distinctly the FRT and GIT microbiomes, with endometriosis showing unique microbial characteristics. We proposed the concept of ‘female holobiont’ as a community that comprises the host and microbes that must maintain overall homeostasis across all body sites to ensure a woman’s health. Insights into these microbial patterns not only advance our understanding of the pathophysiology of infertility but also open new avenues for developing microbe-based therapeutic interventions aimed at restoring microbial balance, thereby enhancing fertility prospects.es
dc.formatapplication/pdfes
dc.format.extent15 p.es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofMicroorganisms, 12 (5).
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMicrobiomees
dc.subjectHolobiontes
dc.subjectOrales
dc.subjectTractes
dc.subjectFemalees
dc.subjectInfertilityes
dc.subjectEndometriosises
dc.titleDistinct Gastrointestinal and Reproductive Microbial Patterns in Female Holobiont of Infertilityes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Estomatologíaes
dc.relation.publisherversionhttps://www.mdpi.com/2076-2607/12/5/989es
dc.identifier.doi10.3390/microorganisms12050989es
dc.journaltitleMicroorganismses
dc.publication.volumen12es
dc.publication.issue5es

FicherosTamañoFormatoVerDescripción
Distinct Gastrointestinal...pdf2.975MbIcon   [PDF] Ver/Abrir  

Este registro aparece en las siguientes colecciones

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como: Atribución 4.0 Internacional