dc.creator | Ballesteros Sánchez, Antonio | es |
dc.creator | Sánchez González, José María | es |
dc.creator | Tedesco, GR | es |
dc.creator | Rocha de Lossada, Carlos | es |
dc.creator | Murano, G | es |
dc.creator | Spinelli, Antonio | es |
dc.creator | Borroni, Davide | es |
dc.date.accessioned | 2024-05-22T11:47:49Z | |
dc.date.available | 2024-05-22T11:47:49Z | |
dc.date.issued | 2023-11-28 | |
dc.identifier.citation | Ballesteros Sánchez, A., Sanchez González, J., Tedesco, G., Rocha de Lossada, C., Murano, G., Spinelli, A. y Borroni, D. (2023). Assessing the Effects of 0.3% Carboxymethylcellulose Tear Substitute Treatment on Symptoms and Signs of Dry Eye Disease in Elderly Population: A Prospective Longitudinal Study. Journal of Clinical Medicine (JCM), 12 (23), 7364. https://doi.org/10.3390/jcm12237364. | |
dc.identifier.issn | 2077-0383 | es |
dc.identifier.uri | https://hdl.handle.net/11441/158811 | |
dc.description.abstract | Background: We aimed to evaluate the effects of 0.3% carboxymethylcellulose (CMC) tear substitute treatment in dry eye disease (DED), as well as treatment compliance and adverse events (AEs). Methods: In this prospective, longitudinal study, a total of 30 eyes receiving 0.3% CMC tear substitute four times daily for DED were evaluated. Clinical endpoints included an ocular surface disease index (OSDI) questionnaire, average non-invasive tear film break-up time (A-NIBUT), lipid layer thickness (LLT), and a Schirmer test with anesthesia (ST). Treatment compliance and AEs were also assessed. All evaluations were performed at 2, 4, and 12 weeks of follow-up. Results: At the end of the follow-up, significant improvement was observed in all clinical endpoints with the following mean values: ΔOSDI questionnaire of −22.53 ± 14.68 points, ΔA-NIBUT of 4.81 ± 2.88 s, ΔLLT of 5.63 ± 6.53 nm, and ΔST of 2.8 ± 2.1 mm (p < 0.001 for all comparisons). Although repeated measures analysis showed that all clinical endpoints presented statistically significant differences (p < 0.001 for all comparisons LLTBaseline–LLT2-weeks (p = 0.460) and LLT4-weeks–LLT12-weeks (p = 0.071) were the only pairs of measures that reported non-statistically significant differences). In addition, treatment compliance was 94.3 ± 5.2% and transient AEs related to the use of 0.3% CMC tear substitute were reported. Conclusions: 0.3% CMC tear substitute treatment seems to achieve beneficial effects on the OSDI questionnaire, A-NIBUT, LLT, and ST. However, further studies at this concentration are needed to confirm these results. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Journal of Clinical Medicine (JCM), 12 (23), 7364. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | carboxymethylcellulose (CMC) | es |
dc.subject | tear substitutes | es |
dc.subject | artificial tears | es |
dc.subject | dry eye disease (DED) | es |
dc.title | Assessing the Effects of 0.3% Carboxymethylcellulose Tear Substitute Treatment on Symptoms and Signs of Dry Eye Disease in Elderly Population: A Prospective Longitudinal Study | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Física de la Materia Condensada | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.relation.publisherversion | https://doi.org/10.3390/jcm12237364 | es |
dc.identifier.doi | 10.3390/jcm12237364 | es |
dc.journaltitle | Journal of Clinical Medicine (JCM) | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 23 | es |
dc.publication.initialPage | 7364 | es |